NALP2 Rabbit pAb(bs-6717R)-50ul/100ul/200ul
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NALP2 Rabbit pAb(bs-6717R)-50u

l/100ul/200ul
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  • ￥1180 - 2800
  • Bioss已认证
  • bs-6717R
  • 2025年10月24日
  • 产品信息以Bioss网站为准
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      50ul/100ul/200ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    产品编号bs-6717R
    英文名称NALP2 Rabbit pAb
    中文名称富含亮氨酸重复结构域蛋白2抗体
    英文别名CLR19.9; FLJ20510; Leucine rich repeat and PYD containing protein 2; LRR and PYD domains-containing protein 2; NACHT; NACHT domain; NACHT leucine rich repeat and PYD containing 2; NACHT LRR and PYD domains containing protein 2; NALP2; NALP2_HUMAN; NBS1; NLR family pyrin domain containing 2; NLRP2; Nucleotide binding oligomerization domain leucine rich repeat and pyrin domain containing 2; Nucleotide-binding site protein 1; PAN1; PYPAF2; PYRIN containing APAF1 like protein2; PYRIN domain and NACHT domain-containing protein 1; PYRIN-containing APAF1-like protein 2.
    产品应用WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Human, Mouse, Rat (Horse, Rabbit)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human NACHT, LRR and PYD domains-containing protein 2
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量117 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cell Biology > Apoptosis > Intracellular > Caspases etc > CARD Family

    Cell Biology > Apoptosis > Intracellular > Caspases etc > Caspases

    亚基Interacts with CHUK, IKBKB and IKBKG, as well as with full-length PYCARD and with the DAPIN domain of NAPL1, but not the full-length protein.
    亚细胞定位Cytoplasm.
    组织特异性Expressed at high levels in lung, placenta and thymus and at lower levels in ovary, intestine and brain.
    相似性Belongs to the NLRP family.
    Contains 1 DAPIN domain.
    Contains 8 LRR (leucine-rich) repeats.
    Contains 1 NACHT domain.
    功能Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料NALP proteins, such as NALP2, are characterized by an N-terminal pyrin (MIM 608107) domain (PYD) and are involved in the activation of caspase-1 (CASP1; MIM 147678) by Toll-like receptors (see TLR4; MIM 603030). They may also be involved in protein complexes that activate proinflammatory caspases (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008].

     

    应用推荐稀释比例
    {WB}{1:500-2000}
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {IF}{1:100-500}

     

    NALP2 Rabbit pAb(bs-6717R)-50u
    Tissue/cell: rat brain tissue; 4% P‌‌araformaldehyde-fixed and paraffin-embedded;
    Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
    Incubation: Anti-NALP2/PAN1/PYPAF2 Polyclonal Antibody, Unconjugated(bs-6717R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
    NALP2 Rabbit pAb(bs-6717R)-50u
    Sample:
    Thymus(Mouse) Lysate at 40 ug
    A431(Human) Cell Lysate at 30 ug
    Molt-4(Human) Cell Lysate at 30 ug
    Primary: Anti-NALP2   (bs-6717R) at 1/500 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 117 kD
    Observed band size: 117 kD
    NALP2 Rabbit pAb(bs-6717R)-50u
    Sample:
    Lane 1: Mouse Thymus tissue lysates
    Lane 2: Mouse Ovary tissue lysates
    Lane 3: Rat Placenta tissue lysates
    Lane 4: Human MCF-7 cell lysates
    Primary: Anti-NALP2 (bs-6717R) at 1/1000 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 117 kDa
    Observed band size: 120 kDa

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    该产品被引用文献

    [IF={{ 3.9 }}] {Jun Yang. et al. A PANoptosis-Based Signature for Survival and Immune Predication in Glioblastoma Multiforme. ANN CLIN TRANSL NEUR. 2025 May;:} {WB} {Human}

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    文献支持
    NALP2 Rabbit pAb(bs-6717R)-50ul/100ul/200ul
    ￥1180 - 2800