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PACAP-27/38 Rabbit pAb(bs-0190

R)-50ul/100ul/200ul
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  • ￥1180 - 2800
  • Bioss已认证
  • bs-0190R
  • 2025年10月24日
  • 产品信息以Bioss网站为准
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      50ul/100ul/200ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    产品编号bs-0190R
    英文名称PACAP-27/38 Rabbit pAb
    中文名称腺苷酸环化酶激活肽-27/38抗体
    英文别名Adenylate Cyclase Activating Polypeptide 1(Pituitary); Prepro-PACAP; PACAP; Pituitary Adenylate Cyclase Activating Polypeptide; PRP-48; PACAP27; PACAP38; ADCYAP1; PACA_HUMAN;
    中文别名Pituitary Adenylate Cyclase-Activating Polypeptide; Adenylate Cyclase Activating Polypeptide 1; PRP48; PACAP-27; PACAP-38;
    产品应用WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Human, Rat (Mouse, Pig, Cow, Sheep)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human PACAP-27/38
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量19 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cell Biology > Apoptosis > Intracellular > Associated Proteins

    Cell Biology > Apoptosis > Intracellular > Caspases etc > Caspases

    Neuroscience > Neurotransmitter > Neuropeptides > Hormones

    亚基Interacts with ADCYAP1R1 (via N-terminal extracellular domain).
    亚细胞定位Extracellular region or secreted
    相似性Belongs to the glucagon family.
    功能Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion. Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料This gene encodes a secreted proprotein that is further processed into multiple mature peptides. These peptides stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the transcriptional activation of target genes. The products of this gene are key mediators of neuroendocrine stress responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]

     

    应用推荐稀释比例
    {WB}{1:500-2000}
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {IF}{1:100-500}

     

    产品细节图片1
    Sample:
    Cerebrum (Rat) Lysate at 40 ug
    Primary: Anti- PACAP-27/38 (bs-0190R) at 1/1000 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 19 kD
    Observed band size: 20 kD

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    图标文献和实验
    该产品被引用文献

    [IF={{ 8.739 }}] {Hailou Zhang. et al. Synergistic effects of two natural compounds of iridoids on rapid antidepressant action by up-regulating hippocampal PACAP signaling. 2022 Mar 31} {WB,IF} {Mouse}

    [IF={{ 5.3 }}] {Alice Meng. et al. mGluR5 in astrocytes in the ventromedial hypothalamus regulates PACAP neurons and glucose homeostasis. J NEUROSCI. 2023 Jul;:} {IF} {Mouse}

    [IF={{ 4.755 }}] {Han Xuke. et al. Effects of electroacupuncture on bladder dysfunction and the expression of PACAP38 in a diabetic rat model. FRONT PHYSIOL. 2022 Dec;13:2751} {WB} {Rat}

    [IF={{ 3.5 }}] {Curtis Genevieve R.. et al. Pituitary adenylate cyclase-activating polypeptide (PACAP)+ cells in the paraventricular nucleus of the thalamus: relationship with binge-type eating in male and female mice. PSYCHOPHARMACOLOGY. 2024 Sep;:1-14} {IF} {Mouse}

    [IF={{ 3.5 }}] {Genevieve R. Curtis. et al.Pituitary adenylate cyclase-activating polypeptide (PACAP)[+] cells in the paraventricular nucleus of the thalamus: relationship with binge-type eating in male and female mice.psychopharmacology.2025 Feb;242(2):413-426.} {IHC} {Mouse}

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    PACAP-27/38 Rabbit pAb(bs-0190R)-50ul/100ul/200ul
    ￥1180 - 2800