Sample:
Lane 1: Human THP-1 cell lysates
Lane 2: Human U937 cell lysates
Primary: Anti-CCR-5 (bs-2514R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 40 kD
Observed band size: 43 kD
- ￥1180 - 2800
- Bioss
- bs-2514R
- 2025年10月16日
- 产品信息以Bioss网站为准
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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-2514R |
| 英文名称 | CCR5 Rabbit pAb |
| 中文名称 | 细胞表面趋化因子受体5抗体 |
| 英文别名 | C-C chemokine receptor 5; CCR5; CC-CKR-5; CCR-5; CCCKR5; CD195; CD 195; CKR-5; CKR5; CMKBR5; FLJ78003; IDDM22; AM4-7; C C chemokine receptor type 5; C-C motif chemokine receptor 5 A159A; CC Chemokine Receptor Type 5; CCR5 chemokine(C C motif) receptor 5; Chemokine receptor CCR5; CHEMR13; HIV 1 Fusion Coreceptor; HIV1 fusion coreceptor; IDDM22; MIP-1 alpha receptor; CCR5_HUMAN. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 交叉反应 | Human |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human CCR-5 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 40 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Signal transduction > G protein signaling > GPCR Cardiovascular > Atherosclerosis > Vascular Inflammation > Leukocyte recruitment > Chemokines Immunology > Immune System Diseases > Antiviral Signaling > HIV-related Immunology > Innate Immunity > Chemokines > Beta Chemokine Rec. (CCR) Immunology > Innate Immunity > Macrophage / Inflamm. Microbiology > Interspecies Interaction > Host Virus Interaction Neuroscience > Neurology process > Neurodegenerative disease > Alzheimer's disease Signal Transduction > Signaling Pathway > G Protein Signaling > GPCR |
| 亚基 | Interacts with PRAF2. Interacts with HIV-1 surface protein gp120. Efficient ligand binding to CCL3/MIP-1alpha and CCL4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on Ser-6 is required for efficient binding of CCL4. Interacts with ADRBK1. Interacts with ARRB1 and ARRB2. Interacts with human cytomegalovirus/HHV-5 protein UL78. |
| 亚细胞定位 | Cell membrane; Multi-pass membrane protein. |
| 组织特异性 | Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1A and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung. |
| 相似性 | Belongs to the G-protein coupled receptor 1 family. |
| 功能 | Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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文献和实验该产品被引用文献
[IF={{ 9.9 }}] {Wu Guanghao. et al. Thylakoid engineered M2 macrophage for sonodynamic effect promoted cell therapy of early atherosclerosis. NANO RES. 2023 Sep;:1-10} {WB,FCM} {Mouse}
[IF={{ 7.3 }}] {Kazuhiro Onuma. et al. Bardoxolone methyl prevents metabolic dysfunction-associated steatohepatitis by inhibiting macrophage infiltration. BRIT J PHARMACOL. 2024 Apr;:} {IHC} {Mouse}
[IF={{ 5.793 }}] {Nicolas Pelisch. et al. CCL3 contributes to secondary damage after spinal cord injury. J Neuroinflamm. 2020 Dec;17(1):1-16} {WB} {Mouse}
[IF={{ 5.719 }}] {Subhra Mandal. et al. Targeted Immuno-Antiretroviral to Promote Dual Protection against HIV: A Proof-of-Concept Study. NANOMATERIALS-BASEL. 2022 Jan;12(11):1942} {FCM} {Human}
[IF={{ 5.714 }}] {Tianming Li. et al. IL-17D affects the chemokines and chemokine receptors of intestinal epithelial cells under hyperoxia. INT IMMUNOPHARMACOL. 2022 Dec;113:109386} {IHC} {Rat, Human}
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CCR5 Rabbit pAb(bs-2514R)-50ul/100ul/200ul
￥1180 - 2800
