Sample:
Lane 1: Human Jurkat cell lysates
Lane 2: Human A549 cell lysates
Lane 3: Human HUVEC cell lysates
Lane 4: Human HeLa cell lysates
Primary: Anti-TNFRSF10A (bs-0591R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 50 kDa
Observed band size: 60 kDa
- ￥1180 - 1980
- Bioss
- bs-0591R
- 2025年10月16日
- 产品信息以Bioss网站为准
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- 规格：
50ul/100ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 产品编号 | bs-0591R |
| 英文名称 | TNFRSF10A Rabbit pAb |
| 中文名称 | 死亡受体4抗体 |
| 英文别名 | TR10A_HUMAN; Tumor necrosis factor receptor superfamily member 10A; APO2; DR4; TRAILR1; Death receptor 4; TNF-related apoptosis-inducing ligand receptor 1(TRAIL receptor 1; TRAIL-R1); CD261; |
| 产品应用 | WB=1:200-500 Not yet tested in other applications. |
| 交叉反应 | Human |
| 抗体来源 | Rabbit |
| 免疫原 | Recombinant human TNFRSF10A protein |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 50 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cardiovascular > Angiogenesis > Endothelial Cell Markers Cell Biology > Apoptosis > Receptors > Death Receptors Immunology > Innate Immunity > Cytokines > TNF Superfamily |
| 亚基 | Can interact with TRADD and RIPK1. Interacts with ARAP1. |
| 亚细胞定位 | Membrane; Single-pass type I membrane protein. |
| 组织特异性 | Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K562 erythroleukemia cells, MCF7 breast carcinoma cells and activated T-cells. |
| 相似性 | Contains 1 death domain. Contains 3 TNFR-Cys repeats. |
| 功能 | Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008] |
| 应用 | 推荐稀释比例 |
| {WB} | {1:200-500} |
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文献和实验该产品被引用文献
[IF={{ 7.129 }}] {Furui Han. et al. In vivo and in vitro study on hepatotoxicity of Tris-(2, 3-dibromopropyl) isocyanurate exposure via mitochondrial and death receptor pathway. ECOTOX ENVIRON SAFE. 2022 Nov;246:114186} {WB} {Rat, Human}
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TNFRSF10A Rabbit pAb(bs-0591R)-50ul/100ul
￥1180 - 1980
