HMGA2 | HMGIC Rabbit pAb(bs-0556R)-50ul/100ul/200ul产品图
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HMGA2 | HMGIC Rabbit pAb(bs-05

56R)-50ul/100ul/200ul
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  • ￥1180 - 2800
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  • bs-0556R
  • 2026年10月13日
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    北京博奥森生物技术有限公司
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    • 规格：

      50ul/100ul/200ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    产品编号bs-0556R
    英文名称HMGA2 Rabbit pAb
    中文名称高迁移率族蛋白A2抗体
    英文别名HMGA 2; BABL; High mobility group(nonhistone chromosomal) protein isoform I C; High mobility group(nonhistone chromosomal) protein isoform IC; High Mobility Group AT hook 2; High Mobility Group AT hook protein 2; High mobility group protein HMGI C; High mobility group protein HMGIC; High mobility group protein I, isoform C; HMGA 2; HMGI C; HMGIC; LIPO; Non histone chromosomal architectural protein HMGI C; Non histone chromosomal architectural protein HMGIC; Pygmy; STQTL9; HMGA2_HUMAN.
    产品应用IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Human (Mouse, Rat, Chicken)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human HMGA2
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量12 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Cell cycle > Cell differentiation

    Developmental Biology > Post embryonic development > Aging

    Epigenetics and Nuclear Signaling > Cell cycle > Cell Differentiation

    Epigenetics and Nuclear Signaling > Histones > HMGs

    Neuroscience > Cell Type Marker > Neural Stem Cell marker

    Neuroscience > Neurology process > Metabolism

    Neuroscience > Neurology process > Neurogenesis

    Stem Cells > Neural Stem Cells > Intracellular

    亚基Interacts with E4F1. Interacts with NEK2 (By similarity).
    亚细胞定位Nucleus.
    翻译后修饰Regulated by cell cycle-dependent phosphorylation which alters its DNA binding affinity. Phosphorylated by NEK2.
    相似性Belongs to the HMGA family._x000D_
    Contains 3 A.T hook DNA-binding domains.
    功能 Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

     

    应用推荐稀释比例
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {IF}{1:100-500}

     

    产品细节图片1
    Tissue/cell: human ovary carcinoma; 4% P‌‌araformaldehyde-fixed and paraffin-embedded;
    _x000D_ Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
    _x000D_ Incubation: Anti-HMGA2 Polyclonal Antibody, Unconjugated(bs-0556R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
    _x000D_

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    图标文献和实验
    该产品被引用文献

    [IF=3.146] Hou, Xiaocan, et al. "Let-7a inhibits migration of melanoma cells via down-regulation of HMGA2 expression." American Journal of Translational Research 8.9 (2016): 3656. WB ="Mouse"

    [IF=2.976] Yang Y et al. MicroRNA-33b-5p is overexpressed and inhibits GLUT4 by targeting HMGA2 in polycystic ovarian syndrome: An in vivo and in vitro study.Oncol Rep. 2018 Jun;39(6):3073-3085. IHC,WB Rat&Human

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    HMGA2 | HMGIC Rabbit pAb(bs-0556R)-50ul/100ul/200ul
    ￥1180 - 2800