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- bs-4597R
- 2025年10月24日
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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-4597R |
| 英文名称 | MMP-1 Rabbit pAb |
| 中文名称 | 基质金属蛋白酶-1抗体 |
| 英文别名 | MMP-1; MMP1; CLGN; CLG; collagenase, fibroblast; Fibroblast collagenase; Interstitial collagenase; Matrix metallopeptidase 1(interstitial collagenase); Matrix metalloprotease 1; Matrix metalloproteinase-1; Matrix Metalloproteinase 1; MMP1_HUMAN; OTTHUMP00000045866; MMP 1. |
| 产品应用 | WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500 Not yet tested in other applications. |
| 交叉反应 | Human, Mouse, Rat (Dog, Cow, Horse, Rabbit, Sheep) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human MMP-1 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 27/41/54 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Invasion/microenvironment > Angiogenesis > ECM enzymes > MMPs Cancer > Tumor biomarkers > Enzymes > MMPs Cardiovascular > Angiogenesis > Adhesion / ECM > Matrix Metalloproteinases > MMP Cardiovascular > Atherosclerosis > Thrombosis > Endothelial mediators/regulators Cell Biology > Proteolysis / Ubiquitin > Proteolytic enzymes > Metalloprotease > MMPs Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > ECM Enzymes > MMP |
| 亚基 | Interacts with HIV-1 Tat. |
| 亚细胞定位 | Secreted, extracellular space, extracellular matrix (Probable). |
| 翻译后修饰 | Undergoes autolytic cleavage to two major forms (22 kDa and 27 kDa). A minor form (25 kDa) is the glycosylated form of the 22 kDa form. The 27 kDa form has no activity while the 22/25 kDa form can act as activator for collagenase. |
| 相似性 | Belongs to the peptidase M10A family. Contains 4 hemopexin-like domains. |
| 功能 | Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc binding site characterizes the structure of the MMPs. In addition, fibronectin like repeats, a hinge region, and a C terminal hemopexin like domain allow categorization of MMPs into the collagenase, gelatinase, stomelysin and membrane type MMP subfamilies. All MMPs are synthesized as proenzymes, and most of them are secreted from the cells as proenzymes. Thus, the activation of these proenzymes is a critical step that leads to extracellular matrix breakdown. MMPs are considered to play an important role in wound healing, apoptosis, bone elongation, embryo development, uterine involution, angiogenesis and tissue remodeling, and in diseases such as multiple sclerosis, Alzheimer's, malignant gliomas, lupus, arthritis, periodontis, glumerulonephritis, atherosclerosis, tissue ulceration, and in cancer cell invasion and metastasis. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
Lane 1: Testis (Rat) Lysate at 40 ug
Lane 2: Testis (Mouse) Lysate at 40 ug
Primary: Anti-MMP-1 (bs-4597R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 54 kD
Observed band size: 54 kD
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文献和实验[IF={{ 6.51 }}] {Woan-Ruoh Lee. et al. Laser-assisted nanoparticle delivery to promote skin absorption and penetration depth of retinoic acid with the aim for treating photoaging. INT J PHARMACEUT. 2022 Nov;627:122162} {WB} {Human}
[IF={{ 5.606 }}] {Luo Ping. et al. IL-37 inhibits M1-like macrophage activation to ameliorate temporomandibular joint inflammation through the NLRP3 pathway. Rheumatology. 2020 Oct;59(10):3070-3080} {WB} {Human}
[IF={{ 5.4 }}] {Daijing Long. et al. TET2 promotes UVB-induced cell death by activating RIPK3-MLKL-necroptosis signaling. CHEM-BIOL INTERACT. 2025 May;:111550} {IHC} {Mouse}
[IF={{ 5.17 }}] {Ou et al. Tumor microenvironment B cells increase bladder cancer metastasis via modulation of the IL-8/androgen receptor (AR)/MMPs signals. (2015) Oncotarge. 6:26065-78} {WB} {Human}
[IF={{ 5.039 }}] {Luo P et al. IL‐37b alleviates inflammation in the temporomandibular joint cartilage via IL‐1R8 pathway. Cell Prolif. 2019 Sep 27:e12692.} {WB,IHC} {Human&Rat}
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