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| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-1025R |
| 英文名称 | HGF Rabbit pAb |
| 中文名称 | 肝细胞生长因子α抗体 |
| 英文别名 | HGF alpha; HGFA; F TCF; Hepatocyte growth factor; Fibroblast derived tumor cytotoxic factor; Hepatocyte growth factor precursor; Hepatopoietin A; HPTA; Lung fibroblast derived mitogen; Scatter factor; SF; hepatocyte growth factor alpha-chain; Hepatocyte growth factor alpha chain; HGF_HUMAN. |
| 产品应用 | WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500 Not yet tested in other applications. |
| 交叉反应 | Mouse, Rat (Human, Dog, Pig, Cow, Horse, Rabbit, Sheep, GuineaPig) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human HGF alpha |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 54/80 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Invasion/microenvironment > Angiogenesis > Angiogenic growth factors Signal Transduction > Growth Factors/Hormones > Hormones |
| 亚基 | Dimer of an alpha chain and a beta chain linked by a disulfide bond. |
| 相似性 | Belongs to the peptidase S1 family. Plasminogen subfamily.
Contains 4 kringle domains. Contains 1 PAN domain. Contains 1 peptidase S1 domain. |
| 功能 | HGF is a potent mitogen for mature parenchymal hepatocyte cells, seems to be an hepatotrophic factor, and acts as growth factor for a broad spectrum of tissues and cell types. It has no detectable protease activity. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | HGF is a pleiotropic protein in the plasminogen subfamily of S1 peptidases. HGF is a potent, mesenchymally-derived mitogen for mature parenchymal hepatocytes, and acts as a growth factor for a broad spectrum of tissues and cell types. HGF signals through a transmembrane tyrosine kinase receptor known as MET. Human HGF is secreted as an inactive 728 amino acid (aa) single chain propeptide. HGF regulates many physiological processes including proliferation, scattering, morphogenesis and survival. HGF is a crucial mitogen for liver regeneration processes, especially after partial hepatectomy and other liver injuries.This recombinant human HGF is produced by human cells. (Tag free) Biological activity: The activity was measured by its ability to stimulate the proliferation of the monkey epithelial cell line 4MBr-5.Reconstitution: Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
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文献和实验[IF={{ 7.3 }}] {Quanyu Chen. et al. Comparative effects of hepatocyte growth factor and tacrolimus on acute liver allograft early tolerance. FRONT IMMUNOL. 2023; 14: 1162439} {IHC} {Rat}
[IF={{ 6.832 }}] {Liu, Jingyu. et al. Therapeutic effect of adipose stromal vascular fraction spheroids for partial bladder outlet obstruction induced underactive bladder. Stem Cell Res Ther. 2022 Dec;13(1):1-16} {WB} {Rat}
[IF={{ 5.1 }}] {Wu, Ka, et al. "Biocharacterization of Heat Shock Protein 90 in Acetaminophen-Treated Livers Without Conspicuous Drug Induced Liver Injury." Cellular Physiology and Biochemistry 43.4 (2017): 1-1.} {WB} {="Mouse"}
[IF={{ 4.158 }}] {Yan, Liting. et al. HGF can reduce accumulation of inflammation and regulate glucose homeostasis in T2D mice. 2021 Aug 07} {IHC} {Mouse}
[IF={{ 4.064 }}] {Ming Ni. et al. Sox11 Modified Tendon-Derived Stem Cells Promote the Repair of Osteonecrosis of Femoral Head:. Cell Transplant. 2021;():} {WB} {Rabbit}
= NAL), appears to form upon oxidative cyclization of the nonfluorescent 2:1 lysine-HNE Michael adduct-Schiff base cross-link (Scheme 1). Polyclonal antibody (PAb) to the NAL-HNE fluorophore was raised in rabbit and found to be highly specific
生长因子 (rabbit HGF) ELISA 48T/96T 1800/2800 进口分装 F20150 兔透明质酸 (rabbit HA) ELISA 48T/96T 2000/3000 进口分装 F20151 兔心脂肪酸结合蛋白 (rabbit
是肝细胞生长因子 (HGF) 的受体。正常的 HGF/MET 信号通路精密调控胚胎发育、组织再生和损伤修复过程中的细胞增殖、分化和迁移。 在肺癌中，MET 可通过基因扩增、蛋白过表达或 14 号外显子 (METex14) 跳跃突变等方式异常激活，导致下游促生长和生存信号通路持续活化，驱动肺癌的生长、存活和转移。MET 扩增/过表达是 EGFR 靶向治疗获得性耐药的重要机制之一[6]。 图 3.人肺癌组织的 MET 免疫组化分析 (HY-P86238)。 Section
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