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- bs-12862R
- 2025年10月24日
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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-12862R |
| 英文名称 | beta subunit Cholera Toxin Rabbit pAb |
| 中文名称 | 霍乱肠毒素β链抗体 |
| 英文别名 | Cholera Toxin beta; beta subunit Cholera Toxin; Cholera enterotoxin B chain; Cholera enterotoxin beta chain; Cholera enterotoxin gamma chain; Cholera enterotoxin subunit B; Cholera toxin B protein; Choleragenoid; CTX B; CTXB; TOX B; TOXB; VC1456; CHTB_VIBCH. |
| 产品应用 | WB=1:500-2000, ELISA=1:5000-10000 Not yet tested in other applications. |
| 交叉反应 | (Cholera Toxin) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from CTXB/beta subunit Cholera Toxin |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 12 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Microbiology > Toxin > Bacterial Toxin > Cholera Toxin |
| 亚基 | The holotoxin (choleragen) consists of a pentameric ring of B subunits whose central pore is occupied by the A subunit. The A subunit contains two chains, A1 and A2, linked by a disulfide bridge. |
| 亚细胞定位 | Secreted. Host cell membrane (Potential). |
| 功能 | The B subunit pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells. It can bind five GM1 gangliosides. It has no toxic activity by itself. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The B subunit of cholera toxin (CtxB) binds to a GM1-ganglioside receptor, a ubiquitous glycolipid cell surface receptor. This binding is widely accepted to initiate toxin action by triggering uptake and delivery of the toxin A subunit into cells. The beta chain has no toxic activity by itself. The holotoxin consists of a pentameric ring of B subunits whose central pore is occupied by the A subunit. The A subunit contains two chains, A1 and A2, linked by a disulfide bridge. The A subunit (and Cholera toxin) activates the adenylate cyclase enzyme in cells of the intestinal mucosa leading to increased levels of intracellular cAMP. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {ELISA} | {1:5000-10000} |
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文献和实验[IF={{ 14.919 }}] {Zhao, Yuanyuan. et al. ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer’s disease models. Nat Commun. 2022 Mar;13(1):1-20} {IF} {Mouse}
[IF={{ 1.54 }}] {Tanaka, Koichi, et al. "Possible role of the myelinated neural network in the parietal peritoneum in rats as a mechanoreceptor." The Anatomical Record (2017).} {IHC} {="Rat"}
【资源】全面归类网址：毕赤酵母表达各种来源蛋白（细菌，真菌，植物，人类等）
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