ATXN10 Rabbit pAb(bs-11806R)-50ul/100ul/200ul产品图

ATXN10 Rabbit pAb(bs-11806R)-5

0ul/100ul/200ul
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  • ￥1180 - 2800
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  • bs-11806R
  • 2026年10月13日
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    北京博奥森生物技术有限公司
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      50ul/100ul/200ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    产品编号bs-11806R
    英文名称ATXN10 Rabbit pAb
    中文名称脊髓小脑共济失调10抗体
    英文别名Ataxin 10; Ataxin-10; ATX10_HUMAN; Atxn10; Brain protein E46 homolog; E46L; FLJ37990; HUMEEP; Like mouse brain protein E46; SCA10; Spinocerebellar ataxia 10; Spinocerebellar ataxia type 10 protein.
    产品应用WB=1:500-2000, Flow-Cyt=2ug/Test

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Mouse, Rat (Human, Dog, Pig, Cow, Horse, Sheep)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human ATXN10/SCA10
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量53 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Neuroscience > Neurology process > Neurogenesis

    亚基Homooligomer. Interacts with OGT. Interacts with GNB2. Interacts with IQCB1.
    亚细胞定位Cytoplasm, perinuclear region.
    组织特异性Expressed in the central nervous system.
    相似性Belongs to the ataxin-10 family.
    功能Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Spinocerebellar ataxia (SCA) is an autosomal dominant neurodegenerative disorder characterized by ataxia and selective neuronal cell loss. SCA is caused by the expansion of a translated CAG repeat, encoding a polyglutamine tract in SCA gene products, known as ataxins. The ataxin proteins are ubiquitously expressed in nervous tissue, but are primarily detected in cerebellum, brain stem and spinal cord in the central nervous system. Ataxin-10 is a cytoplasmic protein that belongs to the family of armadillo repeat proteins. A loss of ataxin-10 in primary neuronal cells causes increased apoptosis of cerebellar neurons. Ataxin-10 interacts with p110, an O-Linked beta-N-acetylglucosamine transferase, and may be important in the regulation of intracellular glycosylation levels and homeostasis in the brain. Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant disorder that causes cerebellar ataxia and seizures. SCA10 is caused by an expansion of an ATTCT pentanucleotide repeat in intron 9 of the ataxin-10 gene.

     

    应用推荐稀释比例
    {WB}{1:500-2000}
    {Flow-Cyt}{2ug/Test}

     

    产品细节图片1
    Blank control: Mouse spleen.
    _x000D_ Primary Antibody (green line): Rabbit Anti-ATXN10 antibody (bs-11806R)
    _x000D_ Dilution: 1μg /10^6 cells;
    _x000D_ Isotype Control Antibody (orange line): Rabbit IgG .
    _x000D_ Secondary Antibody : Goat anti-rabbit IgG-AF647
    _x000D_ Dilution: 1μg /test.
    _x000D_ Protocol
    _x000D_ The cells were fixed with 4% PFA (10min at room temperature)and then permeabilized with PBST for 20 min at room temperature. The cells were then incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed._x000D_
    产品细节图片2
    Sample:
    _x000D_ Brain (Rat) Lysate at 40 ug
    _x000D_ Cerebrum (Mouse) Lysate at 40 ug
    _x000D_ Primary: Anti-ATXN10 (bs-11806R) at 1/1000 dilution
    _x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    _x000D_ Predicted band size: 53 kD
    _x000D_ Observed band size: 52 kD
    产品细节图片3
    Sample:
    _x000D_ Lane 1: Mouse Cerebrum tissue lysates
    _x000D_ Lane 2: Mouse Cerebellum tissue lysates
    _x000D_ Lane 3: Rat Cerebrum tissue lysates
    _x000D_ Lane 4: Rat Cerebellum tissue lysates
    _x000D_ Primary: Anti-ATXN10 (bs-11806R) at 1/1000 dilution
    _x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    _x000D_ Predicted band size: 53 kDa
    _x000D_ Observed band size: 52 kDa

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