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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-9512R |
| 英文名称 | Protein S Rabbit pAb |
| 中文名称 | 蛋白S抗体 |
| 英文别名 | Preproprotein S; Propiece of latent protein S; PROS 1; PROS; PROS_HUMAN; PROS1; Protein S alpha; Protein Sa; PS 21; PS 22; PS 23; PS 24; PS 25; PS 26; PS21; PS22; PS23; PS24; PS25; PS26; PSA; Vitamin K dependent protein S; Vitamin K-dependent protein S. |
| 产品应用 | WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500 Not yet tested in other applications. |
| 交叉反应 | Mouse, Rat (Human, Cow, Horse, Sheep) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Protein S/PROS |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 71 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cardiovascular > Blood > Coagulation > Regulatory Cardiovascular > Blood > Fibrinolysis / Thrombolysis Cardiovascular > Blood > Serum Proteins Kits/ Lysates/ Other > Kits > ELISA Kits > ELISA Kits > Cardiovascular ELISA kits |
| 亚细胞定位 | Secreted |
| 组织特异性 | Plasma. |
| 翻译后修饰 | The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains (By similarity). _x000D_ |
| 相似性 | Contains 4 EGF-like domains. Contains 1 Gla (gamma-carboxy-glutamate) domain. Contains 2 laminin G-like domains. |
| 功能 | Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Protein S (PROS) is a vitamin K-dependent plasma protein that inhibits blood clotting by serving as a cofactor for activated protein C (APC) and facilitates clearance of early apoptotic cells. In the plasma, circulating Protein S becomes inactive upon complexing with C4b-binding protein (C4BP); 60-70% of Protein S circulates in complex with C4BP. Calcium-dependent association of C4BP-Protein S with apoptotic cells influences the regulation of complement activation. Protein S has APC-independent anticoagulant activity through direct inhibition of prothrombin activation via interactions with Factor X A, Factor V A and phospholipids. Autosomal dominant Protein S deficiency (levels 15 to 37% of normal) correlates with severe recurrent venous thrombosis. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
_x000D_ Plasma (Mouse) Lysate at 40 ug
_x000D_ Primary: Anti-Protein S (bs-9512R) at 1/1000 dilution
_x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
_x000D_ Predicted band size: 71 kD
_x000D_ Observed band size: 75 kD
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文献和实验Nucleic Acid Programmable Protein Arrays: Versatile Tools for Array‐Based Functional Protein Studies
:4767‐4774. Madoz‐Gurpide, J., Kuick, R., Wang, H., Misek, D.E., and Hanash, S.M. 2008. Integral protein microarrays for the identification of lung cancer antigens in sera
Intraspinal Transplantation of Mouse and Human Neural Precursor Cells
therapy for Alzheimer's disease. CNS Neurol. Disord. Drug Targets 10:459‐485. Ben‐Hur, T., Einstein, O., Mizrachi‐Kol, R., Ben‐Menachem, O., Reinhartz, E., Karussis, D
Models and Analysis of Atherosclerosis, Restenosis, and Aneurysm Formation in the Mouse
. Ishibashi, M., Egashira, K., Zhao, Q., Hiasa, K., Ohtani, K., Ihara, Y., Charo, I.F., Kura, S., Tsuzuki, T., Takeshita, A., and Sunagawa, K. 2004. Bone marrow‐derived monocyte chemoattractant protein
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