Synthesized peptide derived from the Internal region of human CYP2C19. at AA rangle: 210-290
内容
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化方式
Immunogen affinity purified
浓度
500 ug/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
产品形态
Liquid
保存条件
12 months from date of receipt,-20℃ as supplied. 6 months 2 to 8℃ after reconstitution. Avoid repeated freezing and thawing.
背景资料
Cytochrome P450 2C19 (abbreviated°CYP2C19) encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.
研究类别
1. "Entrez Gene: CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19".2. Fleming I (October 2014). "The pharmacology of the cytochrome P450 epoxygenase/soluble epoxide hydrolase axis in the vasculature and cardiovascular disease". Pharmacological Reviews. 66 (4): 1106–40.
[list_product_images]Western Blot (WB) analysis of Mouse Brain cells using CYP2C19 Polyclonal antibody.|Western Blot (WB) analysis of specific cells using CYP2C19 Polyclonal antibody.[/list_product_images]