For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -2157℃ for several months.
英文名:
Trametinib (GSK1120212)
库存:
详询
供应商:
详询
CAS号:
871700-17-3
规格:
5mg/10mg/50mg/100mg/1ml/10mM
规格:
5mg
产品价格:
¥265.0
规格:
10mg
产品价格:
¥425.0
规格:
50mg
产品价格:
¥785.0
规格:
100mg
产品价格:
¥1280.0
规格:
1ml/10mM
产品价格:
¥264.0
ID:T2125
PURITY:0.98
Formula:C26H23FIN5O4
MolWt:615.39
Appearance:白色粉末
Solubility:G4Soluble in DMSO
Bioactivity:Trametinib is an orally bioavailable inhibitor of mitogen-activated protein kinase kinase (MEK MAPK/ERK kinase) with potential antineoplastic activity. Trametinib specifically binds to and inhibits MEK 1 and 2, resulting in an inhibition of growth factor-mediated cell signaling and cellular proliferation in various cancers. MEK 1 and 2, dual specificity threonine/tyrosine kinases often upregulated in various cancer cell types, play a key role in the activation of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth.