- ￥862 - 5482
- TargetMol
- USA
- T1850
- 2025年07月06日
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- 详细信息
- 技术资料
- 保存条件：
-20°C
- 保质期：
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -1882℃ for several months.
- 英文名：
Balicatib
- 库存：
详询
- 供应商：
详询
- CAS号：
354813-19-7
- 规格：
5mg/10mg/25mg/50mg/100mg/1ml/10mM
| 规格： | 5mg | 产品价格： | ￥862.0 |
|---|---|---|---|
| 规格： | 10mg | 产品价格： | ￥1413.0 |
| 规格： | 25mg | 产品价格： | ￥2626.0 |
| 规格： | 50mg | 产品价格： | ￥4242.0 |
| 规格： | 100mg | 产品价格： | ￥5482.0 |
| 规格： | 1ml/10mM | 产品价格： | ￥957.0 |
ID：T1850
PURITY：0.98
Formula：C23H33N5O2
MolWt：411.54
Appearance：白色粉末
Solubility：G4Soluble in DMSO
Bioactivity：Balicatib is an inhibitor of cathepsin K with IC50 value of 1.4nM [1]. Balicatib is highly selective against cathepsin K over cathepsin B, L and S in the in vitro enzyme assay. However, the selectivity is not so high in cell-based enzyme assay. The lysosomotropic character of balicatib results in its accumulation in lysosomes and the subsequent nonselective off-target effects. The off-target effects also cause the skin adverse events of balicatib. As a cathepsin K inhibitor, balicatib is developed for osteoporosis. It has been reported to reduce the biochemical markers of bone resorption and increase bone mineral density in ovariectomized monkeys. In addition, balicatib shows benefits in new bone formation of postmenopausal women
Status：
Pathways：Enzyme
Target：Cathepsin K inhibitor
Receptor：Cathepsin K
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