- ￥568 - 3159
- TargetMol
- USA
- T1821
- 2025年07月16日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
-20°C
- 保质期：
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -1852℃ for several months.
- 英文名：
CGK 733
- 库存：
详询
- 供应商：
详询
- CAS号：
905973-89-9
- 规格：
5mg/10mg/25mg/50mg/1ml/10mM
| 规格： | 5mg | 产品价格： | ￥568.0 |
|---|---|---|---|
| 规格： | 10mg | 产品价格： | ￥928.0 |
| 规格： | 25mg | 产品价格： | ￥1818.0 |
| 规格： | 50mg | 产品价格： | ￥3159.0 |
| 规格： | 1ml/10mM | 产品价格： | ￥1859.0 |
ID：T1821
PURITY：0.98
Formula：C23H18Cl3FN4O3S
MolWt：555.84
Appearance：白色粉末
Solubility：G4Soluble in DMSO
Bioactivity：CGK 733 is a potent and selective inhibitor of ATM/ATR with IC50 of ~200 nM.
Status：
Pathways：PI3K/Akt/mTOR Signaling
Target：ATM/ATR inhibitor
Receptor：ATM/ATR
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文献和实验cGMP-Dependent Protein Kinases (cGK)
cGMP-dependent protein kinases (cGK) are serine/threonine kinases that are widely distributed in eukaryotes. Two genes—prkg1 and prkg2 —code for cGKs, namely, cGKI and cGKII. In mammals, two isozymes, cGKIα and cGKIβ, are generated
Methods for Identification of cGKI Substrates
The cGMP-dependent protein kinases (cGK), which belong to the family of serine/threonine kinases, exhibit their diverse functions in cells through interaction with a variety of substrate proteins. Several substrates were identified
In Situ Hybridization Using Digoxigenin Labeled Probes
dilution of Anti Digoxigenin-POD (Boehringer Cat. #1207 733). 1) Wash the slides in 1X PBS 2 times for 5 minutes each at room temperature 2) Wash for 2 minutes in 1X PBS/0.1 % Triton-X-100. 3) Rinse in 1X PBS 4) Place the slides horizontally
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