- ￥168 - 237
- TargetMol
- USA
- T1667
- 2025年07月14日
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- 详细信息
- 技术资料
- 保存条件：
-20°C
- 保质期：
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -1707℃ for several months.
- 英文名：
Tandutinib (MLN518)
- 库存：
详询
- 供应商：
详询
- CAS号：
387867-13-2
- 规格：
2mg/5mg
| 规格： | 2mg | 产品价格： | ￥168.0 |
|---|---|---|---|
| 规格： | 5mg | 产品价格： | ￥237.0 |
ID：T1667
PURITY：0.99
Formula：C31H42N6O4
MolWt：562.7
Appearance：白色粉末
Solubility：G4DMSO 5 mg/mL;Ethanol 6 mg/mL
Bioactivity：MLN518 is a novel, oral, small molecule designed to inhibit type III receptor tyrosine kinases, including FLT3, (platelet-derived growth-factor receptor) PDGFR and c-KIT. Tyrosine kinases are enzymes involved in several cellular processes and are known to be activated in cancer cells to drive tumor growth. AML patients with FLT3 mutations experience earlier disease relapse and shorter survival rates compared to patients without these mutations. Approximately 25 to 30 percent of all adult AML patients have a mutation of the FLT3 gene. The use of MLN518 to treat AML has been granted fast-track status by the U.S. Food and Drug Administration. Phase I/II trials are underway.
Status：USAN, INN
Pathways：Tyrosine Kinase/Adaptors
Target：KDR inhibitor;PDGFRβ inhibitor;CSF-1R inhibitor;c-Kit inhibitor;FLT3 inhibitor
Receptor：KDR;PDGFRβ;CSF-1R;c-Kit;FLT3
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