- ￥168 - 945
- TargetMol
- USA
- T1622
- 2025年07月11日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
-20°C
- 保质期：
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -1662℃ for several months.
- 英文名：
Rosiglitazone maleate
- 库存：
详询
- 供应商：
详询
- CAS号：
155141-29-0
- 规格：
2mg/10mg/25mg/1ml/10mM
| 规格： | 2mg | 产品价格： | ￥168.0 |
|---|---|---|---|
| 规格： | 10mg | 产品价格： | ￥505.0 |
| 规格： | 25mg | 产品价格： | ￥945.0 |
| 规格： | 1ml/10mM | 产品价格： | ￥428.0 |
ID：T1622
PURITY：0.99
Formula：C18H19N3O3S.C4H4O4
MolWt：473.12
Appearance：白色粉末
Solubility：G4Soluble in DMSO
Bioactivity：Rosiglitazone maleate is the maleic acid salt form of rosiglitazone, a potent insulin sensitizer, which is used for the treatment of diabetes. Rosiglitazone belongs to a group of compounds, thiazolidinediones (TZDs), which selectively ligate the nuclear transcription factor peroxisome-proliferator-activated receptor-γ (PPARγ). As a TZD, rosiglitazone improves the sensitivity of end organs to insulin through PPARγ activation which poteniates them to lower concentrations of blood glucose. Despite of its beneficial effects of targeting insulin resistance, recent studies has shown that rosiglitazone is associated with several moderate to severe adverse effects, including hemodilution, anemia, weight gain, and edema as well as increased risk for heart failure and myocardial ischemic events.
Status：
Pathways：Metabolism
Target：PPAR agonist
Receptor：PPAR
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文献和实验Applications of Proteomics to the Study of Adipose Tissue
Determination of the complex secretory proteome of adipocytes and its metabolic changes induced by drug treatment such as insulin or rosiglitazone is possible with the advanced proteomics technologies described herein. To study the secreted
Induction of Tolerogenic Dendritic Cells by NF-B Blockade and Fc Receptor Modulation
and in vivo , that NF-κB blockade on DCs by andrographolide or rosiglitazone can significantly enhance the tolerogenic capacity of DCs. Furthermore, we have observed that expression ratio of the activating FcγRIII or the inhibitory FcγRIIb is determinant
sodium maleate pH 5.2 (3 x 5'). 8). en bloc stain in 1% uranyl acetate in maleate buffer pH 5.2 (1 hr RT). Using uranyl acetate at low pH will improve membrane contrast. Analternative contrasting method, which adds even more membrane contrast
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