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- 详细信息
- 技术资料
- 保存条件:
-20°C
- 保质期:
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -1541℃ for several months.
- 英文名:
Vildagliptin (LAF-237)
- 库存:
详询
- 供应商:
详询
- CAS号:
274901-16-5
- 规格:
2mg/10mg/25mg/1ml/10mM
| 规格: | 2mg | 产品价格: | ¥378.0 |
|---|---|---|---|
| 规格: | 10mg | 产品价格: | ¥964.0 |
| 规格: | 25mg | 产品价格: | ¥1701.25 |
| 规格: | 1ml/10mM | 产品价格: | ¥658.0 |
ID:T1502
PURITY:0.985
Formula:C17H25N3O2
MolWt:303.4
Appearance:白色粉末
Solubility:G4Soluble in DMSO
Bioactivity:Vildagliptin, previously identified as LAF237, is a new oral anti-hyperglycemic agent (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. Vildagliptin inhibits the inactivation of GLP-1 and GIP by DPP-4, allowing GLP-1 and GIP to potentiate the secretion of insulin in the beta cells and suppress glucaon release by the alpha cells of the islets of Langerhans in the pancreas. It is currently in clinical trials in the U.S. and has been shown to reduce hyperglycemia in type 2 diabetes mellitus. While the drug is still not approved for use in the US, it was approved in Feb 2008 by European Medicines Agency for use within the EU and is listed on the Australian PBS with certain restrictions.
Status:
Pathways:Proteases/Proteasome
Target:DPP-4 inhibitor
Receptor:DDP-4
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