- ￥108 - 998
- TargetMol
- USA
- T0923
- 2025年07月15日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
2-8°C
- 保质期：
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -959℃ for several months.
- 英文名：
Busulfan
- 库存：
详询
- 供应商：
详询
- CAS号：
55-98-1
- 规格：
2mg/10mg/50mg/200mg/1ml/10mM
| 规格： | 2mg | 产品价格： | ￥108.0 |
|---|---|---|---|
| 规格： | 10mg | 产品价格： | ￥248.0 |
| 规格： | 50mg | 产品价格： | ￥638.5 |
| 规格： | 200mg | 产品价格： | ￥998.0 |
| 规格： | 1ml/10mM | 产品价格： | ￥218.0 |
ID：T0923
PURITY：0.98
Formula：C6H14O6S2
MolWt：246.3029
Appearance：白色粉末
Solubility：G4Soluble in DMSO
Bioactivity：Antineoplastic bifunctional, DNA alkylating agent that causes DNA damage by cross-linking DNA and proteins. Causes double-base lesions mainly at 5'-GA-3' and, to a lesser extent, at 5'-GG-3' sequences. Forms an intrastrand cross-link at the 5'-GA-3' sequence, and to monoalkylation. Induces normal human fibroblast senescence selectively through Erk and p38 pathways
Status：USP, INN, BAN, JAN
Pathways：DNA Damage/DNA Repair
Target：DNA Alkylating
Receptor：DNA
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文献和实验Busulfan is a chemotherapy drug widely used as part of conditioning regimens for patients undergoing bone marrow transplantation (BMT). Challenges of busulfan treatment include a narrow therapeutic window and wide inter- and intra-patient
Dynamics of Claudins Expression in Colitis and Colitis-Associated Cancer in Rat
-7 were ubiquitously expressed in all study groups. As depicted in Fig. 1b, expressions of claudin-2, -12, and -15 significantly diminished after combined treatment with dextran sulfate sodium (DSS) and busulfan (BU) (lane 5), compared with either agent alone (lanes
thiophosphoramide,TSPA）结构中含三个乙撑亚胺基，能形成有活性的碳三离子与细胞内DNA的碱基结合，影响瘤细胞的分裂。其选择性较高，抗瘤谱较广，主要用于乳腺癌、卵巢癌、肝癌和恶性黑色素瘤等，对骨髓有抑制作用，引起白细胞和血小板减少，但较氮芥轻。胃肠道反应少见，局部刺激小，可作静脉注射、肌内注射及动脉内给药与胸（腹）腔内给药。 白消安 白消安（busulfan）又名马利兰（myleran），属磺酸酯类，在体内解离后起烷化作用。小剂量即可明显抑制粒细胞生成，对慢性粒细胞白血病疗效
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