For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -397℃ for several months.
英文名:
Erlotinib
库存:
详询
供应商:
详询
CAS号:
183321-74-6
规格:
10mg/50mg/100mg/1ml/10mM
规格:
10mg
产品价格:
¥108.0
规格:
50mg
产品价格:
¥298.0
规格:
100mg
产品价格:
¥439.0
规格:
1ml/10mM
产品价格:
¥218.0
ID:T0373
PURITY:0.99
Formula:C22H23N3O4
MolWt:393.44
Appearance:白色粉末
Solubility:G4Soluble in water
Bioactivity:Erlotinib hydrochloride (trade name Tarceva, Genentech/OSIP, originally coded as OSI-774) is a drug used to treat non-small cell lung cancer, pancreatic cancer and several other types of cancer. Similar to gefitinib, erlotinib specifically targets the epidermal growth factor receptor (EGFR) tyrosine kinase. It binds in a reversible fashion to the adenosine triphosphate (ATP) binding site of the receptor. Erlotinib has recently been shown to be a potent inhibitor of JAK2V617F activity. JAK2V617F is a mutant of tyrosine kinase JAK2, is found in most patients with polycythemia vera (PV) and a substantial proportion of patients with idiopathic myelofibrosis or essential thrombocythemia. The study suggests that erlotinib may be used for treatment of JAK2V617F-positive PV and other myeloproliferative disorders.