- ¥1000 - 1600
- abcam
- 美国
- KL-KT-001535
- 2025年07月09日
- WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
- Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep,
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- 详细信息
- 文献和实验
- 技术资料
- 亚型：
IgG
- 保存条件：
-20度
- 克隆性：
多克隆
- 适应物种：
Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep,
- 应用范围：
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
- 浓度：
1mg/ml
- 抗体英文名：
Rabbit Anti-FLAP antibody
- 抗体名：
Rabbit Anti-FLAP antibody
- 规格：
0.1ml/0.2ml
Concentration: 1mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background: Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.
Involvement in disease: Genetic variations in ALOX5AP may be a cause of susceptibility to ischemic stroke (ISCHSTR) ; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
Also known as: 5-lipoxygenase activating protein; Arachidonate 5 lipoxygenase activating protein; 5-lipoxygenase activating protein; AL5AP_HUMAN; ALOX 5AP; ALOX5 AP; ALOX5AP; Arachidonate 5-lipoxygenase-activating protein; Five lipoxygenase activating protein; FLAP; MK 886 binding protein; MK-886-binding protein.
Specificity: ● Rabbit Polyclonal IgG, affinity purified by Protein A.
● Reacts with: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, .
● Immunogen: KLH conjugated synthetic peptide derived from human FLAP/5-lipoxygenase activating protein.
● Predicted Molecular Weight: 18kDa.
Storage: Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles). Application: WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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文献和实验-activating protein (FLAP) is essential for leukotriene biosynthesis in response to cellular activation. The crystal structures of human FLAP with two inhibitors were recently determined. Inhibitors are bound within the lipid-exposed portion of FLAP
ARF GTPase-Activating Protein 1
of intrinsic GTPase activity, and GTP hydrolysis depends on the action of GTPase-activating proteins (GAPs). ARF GAPs are a family of proteins which contain a conserved GAP domain of approx 130 amino acids with a unique Cys4 zinc-finger motif near their amino
(for reviews, see refs. 1 and 2 ). By sequence homology of G protein α-subunits, they are divided into four subfamilies, Gs , G1 , Gq , and G12 . Agonist bindmg is assumed to induce a conformational change of the receptor, which causes exchange of GDP for GTP
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