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Cytokines & Receptors: CCL5 (RANTES), CCL7 (MCP-3), CCR3, CCR4, CCR5, CCR6, IL12B, IL12RB2, IL13, IL13RA1, IL17A, IL17RE, IL18, IL18R1, IL18RAP, IL1R1, IL1R2, IL1RL1, IL2, IL21, IL2RA, IL4, IL4R, IL5, IL9, TNF.
T Helper 1 Subtype Markers: CCR5, HAVCR2, IGSF6, IL12B, IL18, IRF1, SOCS1, SOCS5, TLR4, TLR6, TNF.
T Helper 2 Subtype Markers: CCL5 (RANTES), CCL7 (MCP-3), CCR3, CCR4, CEBPB, GFI1, GPR44, ICOS, IL13RA1, IL4R, JAK1, NFATC1, NFATC2.
Transcription Factors: CEBPB, FOSL (FRA-1)1, FOXP3, GATA3, GATA4, HOXA10, HOXA3, ID2, IRF4, IRF8, MAF, NFATC1, NFATC2, NR4A1, NR4A3, POU2F2, REL, RELB, RORA, RORC, RUNX1 (AML1), RUNX3, STAT1, STAT4, STAT6, TOX, ZBTB7B.
Epigenetically Regulated Genes: Th1 Cells: EOMES, IFNG, IL12RB2, IL18R1, IL18RAP, FASLG (TNFSF6), TBX21.
Th2 Cells: ASB2, GATA3, IL13, IL1RL1, IL4, IL5, PPARG.
Th17 Cells: IL17A, IL17RE, IL1R1, IL21, RORA, RORC.
Inducible and Natural Regulatory T (iTreg and nTreg) Cells: CCR6, FOSL1 (FRA-1), FOXP3, IKZF2, IL9, IRF4, IRF8, MYB, NR4A1, NR4A3, POU2F2, REL, RELB, TGIF1, TNFSF11.
Conventional Versus Regulatory T Cells: CACNA1F, CHD7, FOXP3, GATA4, HOPX, HOXA10, HOXA3, ID2, IKZF2, IL1R2, IL2RA, KIF2C, LRRC32, PERP, PKD2, TNFRSF9, TP53INP1, UTS2
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文献和实验在T细胞中，在免疫反应过程本身不是最后的功能细胞（效应器），而可辅助各功能细胞由相应的前体细胞分化出来，这种细胞总称为辅助细胞，亦称辅助T细胞（helper T cell）。辅助细胞的前体细胞在识别抗原的同时，可受A细胞的刺激而活化，分化为辅助细胞，辅助B细胞分化为抗体产生细胞，或T细胞分化为障碍性T细胞。但对一些抗原（革兰氏阴性菌的多核糖体、沙门氏杆菌的鞭毛蛋白和葡聚糖、肺炎球菌的多糖体等）来说，在产生抗体时并不需要辅助细胞，这种抗原称为非依赖于T细胞抗原。辅助细胞可产生并分泌增殖
CD4+ T helper (Th) cells are crucial for the generation of the antigen-specific immune response (1 ). They regulate many different aspects of the immune response, both by the secretion of cytokines and through cell surface expressed molecules
Activation, proliferation and differentiation of na�ve B lymphocytes into memory B cells and plasma cells requires engagement of the B cell receptor (BCR) coupled to T-cell help (1 , 2) . T cells deliver help in cognate fashion
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