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- 文献和实验
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Nuclear Receptors: Androgen Receptors and Related Molecules: AR, MED14, MED17, MED12, MED4, NR1I3, MED1, MED13, MED24, MED16.
Estrogen Receptors and Related Molecules: ESR1, ESR2, NCOA6, PPARGC1B.
Glucocorticoid Receptors and Related Molecules: NCOA6, NR3C1.
Retinoic Acid Receptors and Related Molecules: HMGA1, NCOA6, RARA, RARB, RARG, RXRA, RXRB, RXRG.
Thyroid Hormone Receptors and Related Molecules: BRD8, MED14, MED17, MED12, MED4, NCOA3, NCOA4, NCOA6, NR1D1, NR1H3, NR1I3, NR2F6, MED1, THRA, MED13, MED24, MED16, THRB.
Vitamin D Receptors and Related Molecules: MED14, MED17, MED12, MED4, MED1, MED13, MED24, MED16, VDR.
Steroid Hormone Receptors: ESRRA, ESRRB, ESRRG, HNF4A, NR0B1, NR0B2, NR1D1, NR1D2, NR1H2, NR1H3, NR1H4, NR1I2, NR2C1, NR2C2, NR2E3, NR2F1, NR2F2, NR2F6, NR3C2, NR4A1, NR5A1, NR6A1, PPARA, PPARD, PPARG, RARA, RARB, RARG, RORA, RXRA, RXRB, RXRG, THRA, THRB, VDR.
Other Nuclear Receptors: AHR, TRIP4.
Transcription Factors and Regulators: Ligand-dependent Nuclear Receptor Transcription Coactivators: MED14, MED17, HMGA1, MED12, MED4, NCOA6, MED1, PPARGC1A, PPARGC1B, MED13, MED24, MED16.
Positive Regulators of Transcription: ARNT, BRD8, CREBBP, ESR2, KAT5, NCOA1, NCOA2, NCOA3, NCOA4, NFKB2, NR1H3, NR1I2, NR1I3, NR2C2, NR2F1, NR5A1, NRIP1, PSMC3, RARA, RXRA, RXRB, TRIP4.
Negative Regulators of Transcription: COPS2, HDAC4, HDAC5, HDAC6, HDAC7, NCOR1, NCOR2, NR0B2, NR1D1, NR2F2, PSMC3, PSMC5, THRA, THRB.
Other Transcription Factors and Regulators: AHR, AR, ESR1, ESRRA, ESRRB, ESRRG, HDAC1, HDAC2, HDAC3, HNF4A, ITGB3BP, MTA1, NOTCH2, NR0B1, NR1D2, NR1H2, NR1H4, NR2C1, NR2E3, NR2F6, NR3C1, NR3C2, NR4A1, NR6A1, KAT2B, PPARA, PPARD, PPARG, RARB, RARG, RBPJ (RBPSUH), RORA, RXRG, VDR.
Chromatin Modification Molecules: Histone Acetylation: KAT5, NCOA1, NCOA3, KAT2B.
Histone Deacetylation: HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7.
Other Chromatin Modification Molecules: ESR1, HMGA1, NCOA6, PPARGC1B.
Other Nuclear Receptor Co-regulators: DDX5, TGS1, NONO.
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文献和实验Characterization of Nuclear Receptor Ligands by Multiplexed Peptide Interactions
, although described for nuclear receptors, may also be applied to other types of molecular interactions. Keywords: Microsphere; flow cytometry; nuclear receptor; coactivator; corepressor; cofactor; agonist; antagonist; ligand; ligand binding
extension followed by PCR in the presence of a modified nucleotide. The amplified DNA is fluorescently labeled in a reaction that couples dye to the modified nucleotide, and the labeled sample is hybridized to a microarray representing a complete genome
Gel-Shift Analysis and Identification of RXREs and RAREs by PCR-Based Selection
receptoketinoic X receptor [RAR/RXR]) or in a homodimeric (RXR/RXR) configuration (2 ). If the protein source is a complex-cellular extract, one can distmguish between these possibilities by comcubation with specific antibodies to the receptors. When antibodies
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