G蛋白偶联信号通路发现者PCR芯片G-Protein-Cou

GPCR信号通路发现者PCR芯片包含84个与GPCR调控的信号转导通路相关基因的表达。芯片中包括的GPCRs包括：生物活性的脂受体、代谢型谷氨酸受体（mGluRs）、伽马氨基丁酸B型受体、视紫红质样受体和分泌素样受体。芯片也包含了GPCR介导的信号通路相关的细胞内信号转导通路的复杂网络成员，具体包括：cAMP/PKA信号通路、Calcium/PKC信号通路、Calcium/NFAT信号通路、PLC信号通路、酪氨酸蛋白激酶信号通路、PKC/MEK信号通路、p43/p44MAP信号通路、p38MAP信号通路、PI-3 Kinase信号通路、NO-cGMP信号通路、Rho信号通路、NFkB信号通路和Jak/Stat信号通路。使用这一芯片试剂盒及配套试剂检测RNA实验标本，研究者可以简单准确的检测和分析GPCR调控的信号转导通路相关的基因表达。
G-Protein-Coupled Receptors (GPCRs) Bioactive Lipid Receptors: S1PR1, LPAR1, S1PR3, LPAR2, S1PR2. Metabotropic Glutamate, GABA-B-like Receptors: CASR, GRM1, GRM2, GRM4, GRM5, GRM7. Rhodopsin-like Receptors: ADORA2A, ADRB1, ADRB2, AGTR1, AGTR2, AGTRAP, DRD1, DRD2, S1PR1, LPAR1, S1PR3, LPAR2, S1PR2, GALR2, LHCGR, OPRD1, OPRK1, PTGDR, RHO, TSHR. Secretin-like Receptors: ADORA2A, BAI1, CALCR, CALCRL, CRHR1, CRHR2, GCGR, PTH1R, SCTR. Other G-protein Coupled Receptors: EDN1. Pathways Related to G-Protein-Coupled Receptor Protein Signaling Dopamine Receptor Pathway: DRD1, DRD2, OPRD1. G-protein Signaling, Coupled to cAMP Nucleotide Second Messenger (cAMP / PKA):ADCY5, ADORA2A, ADRB1, ADRB2, CALCR, CALCRL, CCL2, COL1A1, CRHR1, CRHR2, CYP19A1, DRD1, S1PR1, S1PR3, EDN1, GALR2, GCGR, GNAQ, GNAS, GRM2, GRM4, IL1R1, IL1R2, LHCGR, NOS2, OPRD1, OPRK1, PTGS2, PTH1R, RGS2, TSHR, UCP1, VEGFA. G-protein Signaling, Coupled to IP3 Second Messenger (PLC): AGTR1, CALCR, CASR, LPAR1, LPAR2, EDN1, GNAQ, GRM5, PIK3CG. Metabotropic Glutamate Receptor Pathway: GRM1, GRM2, GRM4, GRM5, GRM7. Neuropeptide Signaling Pathway: BAI1, OPRD1. Adenosine Receptor Signaling Pathway: ADCY5, ADORA2A. Calcium Signaing Pathway (PKC, NFAT,etc.): CCL2, CCL4, COL1A1, EGR1, ELK1, ELK4, PTGS2. PKC Pathway (Ca2+, MEK, etc.): AGTR2, COL1A1, DUSP14, EGR1, FGF2, FOS, IL1R1, IL1R2, JUN, JUNB, MMP9, MYC, NOS2, PRKCA, PTGS2, RGS2, SERPINE1, SOCS1. Protein Tyrosine Kinase Pathway: ADRB2, AKT1, CCL4, CTGF, PDPK1, PRKCA, RGS2, SOCS1, YWHAZ. Protein Serine / Threonine Kinase Pathway: AKT1, CDKN1B, PDPK1, PTGDR. MAPKKK Cascade: ADRB2, AGT, S1PR2, FGF2, GRM1, GRM4, PRKCA, TNF, UCP1. PI-3 Kinase Pathway: AKT1, BCL2, BCL2L1, CCND1, CDKN1B, CFLAR, PDPK1, PIK3CG, PTGS2. NO-cGMP Pathway: AGTR2, NOS2, PTGS2, TNF. Rho Pathway: CDKN1B, CTGF, FOS, IL1B, PTGS2, RHO, SERPINE1. IκB Kinase / NFκB Cascade: AGT, CFLAR, LPAR1, ICAM1, IL1B, IL2, MAX, NOS2, PTGS2, TNF, VCAM1. JAK-STAT Cascade: CCL2, CDKN1A, SOCS1. Other Genes Related to G-Protein-Coupled Receptor Protein Signaling: ARRB1, ARRB2, CCNE1, CCNE2.