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Amino Acid Transferases: AGXT, BAAT, CCBL1, GLYAT.
Dehydrogenases: NQO1, NQO2, XDH. Epoxidases: EPHX1, EPHX2.
Esterases: CES1, CES2, CES3, CES5A (CES7).
Glucuronosyltransferases: DDOST, UGT1A1, UGT1A4, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UGT3A1, UGT8.
Glutathione Transferases: GSTA1, GSTA3, GSTA4, GSTA5 (YC2), GSTK1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO1, GSTO2, GSTP1, GSTT1, HNMT, INMT, MGST1, MGST2, MGST3, PTGES.
Methyltransferases: AS3MT, ASMT, COMT, GAMT, GNMT, NNMT, PNMT, TPMT.
N-Acetyltransferases: AANAT, ACSL1, ACSL3, ACSL4, ACSM1, ACSM2B, ACSM3, GALNT1, GALNT4, GCNT1, MGAT1, MGAT2, NAT1, NAT2, NAA20 (NAT5), POMGNT1, SAT1, UGCG.
Sulfotransferases: CHST7, SULT1A1, SULT1A2, SULT1B1, SULT1C4, SULT1C2, SULT1C3, SULT1E1 (STE), SULT2A1, SULT2B1, SULT4A1, SULT6B1, TST.
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文献和实验Hepatocyte Cultures in Drug Metabolism and Toxicological Research and Testing
, and more specifically hepatocyte-based in vitro models, are currently being applied. A major problem, however, related to the use of hepatocytes and their cultures is their limited viability, which is associated with the loss of phase I and phase II biotransformation
Use of Caco-2 Cell Monolayers to Study Drug Absorption and Metabolism
, they have been used to determine the efflux mechanisms of phase II conjugates of drugs and natural products. However, Caco-2 cells do not always express appropriate amounts of transporters or enzymes, which may introduce bias in the determination of their transport
Chimeric Mice with Humanized Liver: Tools for the Study of Drug Metabolism, Excretion, and Toxicity
to Phase I and Phase II metabolic pathways and the expression of hepatic transport proteins. While the studies are still at the descriptive stage, it is already clear that some humanized mice display high levels of repopulation with human hepatocytes
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