Cardiotoxicity PCR Array 心脏毒性基

心脏毒性基因表达PCR芯片可用于研究由药物或化合物诱导而发生心脏损伤的84个关键基因的表达。该芯片包含了多个模型中由于药物或化合物引起的心脏损伤的生物标志物基因，既减少了实验周期和成本，也能在研究最初阶段就发现和剔除会引起心脏毒性反应的药物。利用该芯片研究者即能够利用该芯片简单可靠地同时检测心脏毒性相关基因的表达。
Up-Regulated: Muscle Contraction: KBTBD10.
Angiogenesis: IL6, PLAU, SERPINE1, TGFB2.
Signal Transduction: ABRA, ADRA2A, CCR1, CREM, IL6, RND1, SIK1, TGFB2, TIAM1.
Cell Cycle: BCAT1, FOSL1, HSPA2, SIK1, TGFB2.
Development: BTG2, CREM, EGR1, FHL1, HSPA2, IL6, RND1, SIK1, SPP1, TGFB2, TIAM1, TIMP1, UCP1, VCAN.
Metabolism (Regulation & Mechanism): ABRA, ADRA2A, BTG2, CH25H, CREM, EGR1, FOSL1, IL6, PDK4, PLA2G4A, PUM2, RBM3, SIK1, TCF4, TGFB2, TIMP1.
Migion / Motility: ABHD2, CCL7, CCR1, FOSL1, IL6, PLAU, PPBP, PVR, TGFB2. Other: CD14, CFD, CKM, FCGR2B, GPM6A, HAMP, KBTBD5, MT1F, PLUNC, REG3G, TUBB6, UCK2.
Down-Regulated: Muscle Contraction: ACTA1, GJA1, KCNJ12, RPS6KB1.
Angiogenesis: COL15A1, POSTN, VEGFA.
Signal Transduction: AIFM1, DUSP8, GJA1, IGFBP5, ITPR2, RPS6KB1, S1PR2, THRAP3. Cell Cycle: CSNK2A2, MCM6, PSMA2, PSMD7, TXNIP.
Development: ACTA1, COL15A1, COL3A1, GJA1, IGFBP5, PLN, RPS6KB1, SOX4, TXNIP.
Metabolism (Regulation & Mechanism): ASH1L, ATP5J, DUSP8, IGFBP5, MCM6, NFIB, PPP1R14C, PRKAB2, S1PR2, SOX4, THRAP3, TXNIP, ZNF148, ZNF23.
Migion / Motility: IGFBP5, NEXN, RPS6KB1.
Other: AK3, BGN, BSN, HSPH1, IFT20, PKN2, SLC4A3, UBA5, UBXN2A, VIM, WIPI1.