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文献和实验High-Throughput Production of Gene Replacement Mutants in Neurospora crassa
The model filamentous fungus Neurospora crassa has been the focus of functional genomics studies for the past several years. A high-throughput gene knockout procedure has been developed and used to generate mutants for more than two-thirds
In Vitro Model of Human Articular Cartilage Degradation
Rheumatoid arthritis is characterized by inflamed joints with proliferating synovium and erosion of cartilage and bone. Eventually, loss of articular cartilage leads to a necessity for joint replacement surgery. Elucidation of the mechanisms
Utility of the Ovariectomized Rat as a Model for Human Osteoporosis in Drug Discovery
, can be prevented by estrogen replacement. Because of the striking resemblance of skeletal responses in humans and rats in the state of estrogen deficiency, the ovx rat is considered to be a gold standard model for evaluating drugs for prevention and reversal
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