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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
CD47
- 亚型:
Mouse IgG1
- 形态:
PBS pH 7.2, 0.09% NaN3, 0.2% BSA
- 保存条件:
Store at 4°C and protected from prolonged exposure to light. Do not freeze.
- 克隆性:
Monoclonal Antibody
- 标记物:
PE
- 适应物种:
Hu
- 宿主:
Mouse
- 应用范围:
FC
- 浓度:
Concentration:0.5 mg/ml
- 靶点:
Clone number:B6H12
- 抗体英文名:
CD47 Antibody-PE;流式抗体
- 抗体名:
CD47 Antibody-PE;流式抗体
- 规格:
25/100 tests
克隆类型 :Mouse Monoclonal Antibody;Clone number:B6H12
货 号 :HT1610969
规 格 :25/100 tests;
亚 型 :
Mouse IgG1
浓 度 :
Concentration:0.5 mg/ml
缓 冲 液 :
PBS pH 7.2, 0.09% NaN3, 0.2% BSA
产品描述 :
CD47 antigen, also known as integrin-associated protein (IAP), is expressed on all hematopoietic cells, including leukocytes, platelets and erythrocytes. It is also expressed on epithelial cells, endothelial cells, fibroblasts and many tumor cell lines. CD47 may play a role as a signal transducer in the regulation of cation fluxes across cell membranes and in the chemotactic and adhesive interactions of leukocytes with endothelial cells. B6H12 antibody is capable of blocking phagocytosis of microparticles by peripheral blood granulocytes. It has also been reported to induce proliferation of CD3-activated T cells.
适用物种 :
Hu
应用范围 :
FC
应用说明 :
The amount of the reagent is suggested to be used from 20 µL to 5 µL per 100 µL of peripheral blood.
保存条件 :
Store at 4°C and protected from prolonged exposure to light. Do not freeze.
标 记 物 :
PE(其他荧光标记请咨询我们)
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文献和实验Cruz, CA), anti-CD49f (clone GoH3, PharMingen) and secondary antibodies conjugated to phycoerythrin (PE, 1:100 dilution, Jackson ImmunoResearch, West Grove, PA). Next, 5 105 to 106 GFP+ PE+ infected cells (3ZF library) or 107 GFP+ PE+ infected cells
从免疫防线到促癌帮凶:Elabscience一文读懂肿瘤微环境中的巨噬细胞!
免疫应答: (1)表达PD-L1、B7-H4等免疫检查点分子,直接抑制T细胞功能; (2)分泌IL-10、TGF-β等免疫抑制性细胞因子; (3)表达精氨酸酶1(ARG1),耗竭肿瘤微环境中的L-Arg,导致T细胞受体表达下调; (4)通过CD47/SIRPα轴传递"不要吃我"信号,抑制巨噬细胞自身的吞噬活性。 4. 促进肿瘤干细胞维持和转移 TAMs通过分泌IL-10、TGF-β等因子维持肿瘤干细胞特性,促进上皮-间充质转化。在肺、肝、乳腺等肿瘤中,TAMs通过IL-6/STAT3、TGF-β/Smad等信号
-determining regions (CDR's) located at the ends of the Fab domains. Antibodies are synthesized by B lymphocytes. Each B lymphocyte is capable of producing a single type of antibody directed against a specific structural determinant
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