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- 国食药监械注册号:
无
- 库存:
100
- 供应商:
玉研仪器公司
- 现货状态:
现货:痛觉测试台,小鼠痛觉测试台,大鼠痛觉测试台
- 保修期:
12个月
- 规格:
敬请来电咨询
小鼠、大鼠足底刺痛实验凿孔实验台可配合电子测痛仪或者Von Frey纤毛机械刺激针,完成对大小鼠足底测痛的实验。
包含凿孔台和鼠笼两部分,凿孔台又均匀分布、由激光切割的多孔板支架制作,光滑平整,对老鼠足底没有额外的刺激;
鼠笼为全透明亚克力材质,上下通气,利于实验人员观察的同时,也给老鼠营造了一个安全舒适的测试环境。
小动物足底触觉测试平台配合Von Frey Hairs纤毛机械刺激针或Von Frey电子测痛仪,对大鼠、小鼠进行足底触觉测试。
足底测试平台由三部分组成:凿孔台、测试鼠笼和镜子(其中镜子作为选配配置,请根据需要进行选择)
多种型号可选:
6008型(采用激光切割圆孔板,可同时放置8只小鼠或2只大鼠)
6012型(采用激光切割圆孔板,可同时放置12只小鼠或3只大鼠)
6108型(采用不锈钢丝方形孔板,可同时放置8只小鼠或2只大鼠)
6112型(采用不锈钢丝方形孔板,可同时放置12只小鼠或者3只大鼠)
6112R型---根据实验需求订做尺寸
6115型 兔子测试固定平台

型号:6008,6012 测试平台

型号:6108,6112 测试平台

型号:R2M8-L 测试笼*3个

型号:6115 兔子测试固定平台

型号:6210,6212 镜子
通过观察三棱镜的反射,可辅助实验员对动物足底的准确定位
根据实验需要,可选择Von Frey纤毛机械刺激针 进行触觉测试实验
Von Frey Hairs纤毛机械刺激针是由20根不同规格的Von Frey纤毛机械刺激针组成,英文中也称为Von Frey filaments 或 Semmes-Weinstein monofilaments,主要用于评估皮肤的机械痛阈或触觉阈测量。
每一根纤维丝都有行业中的固定标准,代表了一点的力度值。由于其操作方便,简单易用,价格实惠,在世界各地拥有很多忠实的粉丝,在临床应用和临床前研究中都得到了很成功的应用。

电子式触觉疼痛测量仪
电子触觉测试仪可用来替代传统的Semmes-Weinstein(Von Frey Hairs)纤毛机械刺激针,可直接测得动物的机械痛阈和触觉阈测量,不需要进行反复的测试和繁杂的计算。设备轻巧易用,测量精确。
电子触觉测试仪相比传统方法的优势特点:
· 使用电子触觉测试仪进行一个测试实验,只需要进行一次足底刺激即可得到准确的结果;
· 数据可直接用于统计分析,能够节省很多的精力和时间;
· 测量精度高,测试力度能够读取到1000g以内的具体数值,精度可达0.1g;
· 不需要进行繁杂的统计和计算;
· 使用一个标准直径的刚性探针进行测试,能够避免不同力度纤维丝具有不同的直径而产生的触觉误差;
· 能够避免因为反复多次的测试对动物耐受力的影响,减小测试误差;

动物动态足底触觉测量仪
动态足底触觉仪是评估大鼠、小鼠足底对触觉敏感性的测试设备。
动物模型的刺痛测试与分析在药物诊断、神经病理学和机体损伤性研究等多种研究领域有着广泛的应用。

型号:37550
主要特色
· 自动检测动物反应,无需人为判断;
· 可调节施加力的测试速率;
· 带统计和分析软件;
· 可通过U盘进行数据拷贝;
· 可选配打印机对数据进行打印;
· 可选配鼠筒可进行口部、面部刺激

测试主机

触觉刺激器

测试主机显示面板
主要配置
· 便携和易用移动的触觉刺激器,配有刚性探针和可调节角度的镜子;
· 控制主机,带触控屏,显示直观,操作方便;
· 十字孔板测试平台;
· 模块化动物鼠笼:使用隔板可分配成3个大鼠鼠笼和12个小鼠鼠笼测试单元;

电控型测试探针

测试平台

十字测试网格
设备的操作
· 大鼠、小鼠被放置到测试平台上,用测试鼠笼约束;
· 受试动物在鼠笼内科自由活动;
· 给出一定的环境适应时间和老鼠的探索时间;
· 操作人员将触觉刺激器放置在动物爪子正下方,在反光镜的帮助下定位硬丝;
· 启动触觉刺激器的按钮开始测试;
A:刚性探针被自动抬高;
B:探针接触足底后,开始施力;
C:力度以预设施力速率增加,直到动物移除爪子或达到预设力度,自动停止加力;
· 自动记录两个测试指标:缩爪的潜伏期(单位:S)和缩爪时的力度(单位:g)
数据的采集
· 测试主机可直观显示测试数据,并对数据进行存储;
· 数据可导出到电脑,或者使用专用U盾进行数据拷贝;
· 通信由基于CUB Data Acquisition Windows®的专用软件包52050-10管理;
· 能够将实验数据传送到电脑并使用常用软件进行管理;
· 配备了存储键,用于记录回顾实验数据;
· 支持使用远程网络连接测试主机,对实验参数进编辑;

参考文献:
l R. Lu, A. Schmidtko: “Direct Intrathecal Drug Delivery in Mice for Detect-ing In Vivo Effects of cGMP on Pain Processing” Methods in Molecular Biology 1020: 215-221, 2013
l I.Q. Russe et alia: “Activation of the AMP-Activated Protein Kinase Reduces Inflammatory Nociception” Journal of Pain 2, 2013
l J. Btesh et alia: “Mapping the Binding Site of TRPV1 on AKAP79: Implications for Inflammatory Hyperalgesia” J. Neuroscience 33 (21): 9184-9193, 2013
l V. Brázda et alia: “Dynamic Response to Peripheral Nerve Injury Detected by In Situ Hybridization of IL-6 and its Receptor mRNAs in the Dorsal Root Ganglia is not Strictly Correlated With Signs of Neuropathic Pain” Molecular Pain 9(42), 2013
l D. Piomelli et alia: ”Anandamide Suppresses Pain Initiation Through a Peripheral Endocannabinoid Mechansmsm” Nature NSC , 2010
l P.J. Austin et alia: “G. Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats” JoVE 61, e3393, doi:10.3791/3393, 2012




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