KN-93/kN93,CaMK II抑制剂

KN-93/kN93,CaMK II抑制剂

Item № 13319
CAS № 139298-40-1
Purity ≥98% KN-

93 is a selective inhibitor of Ca²⁺/calmodulin-dependent kinase type II (CaMKII), competitively blocking CaM binding to the kinase (K_i = 370 nM).¹ It does not affect the activities of PKA, PKC, MLCK, or Ca²⁺-phosphodiesterase.¹ It inhibits histamine-induced aminopyrine uptake in parietal cells (IC₅₀ = 300 nM).² More recently, KN-93 has been used to implicate roles for CaMKII in Ca²⁺-induced Ca²⁺ release in cardiac myocytes, constitutive phosphorylation of 5-lipoxygenase in 3T3 cells, and Ca²⁺-dependent activation of HIF-1α in colon cancer cells
Formal Name

	N-[2-[[[3-(4-chlorophenyl)-2-propen-1-yl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxy-benzenesulfonamide
CAS Number	139298-40-1
Molecular Formula	C26H29ClN2O4S
Formula Weight	501.0
Purity	≥98%
Formulation	A crystalline solid
λmax	251 nm
SMILES	CN(C/C=C/C1=CC=C(Cl)C=C1)CC2=CC=CC=C2N(S(=O)(C3=CC=C(OC)C=C3)=O)CCO
InChI Code	1S/C26H29ClN2O4S/c1-28(17-5-6-21-9-11-23(27)12-10-21)20-22-7-3-4-8-26(22)29(18-19-30)34(31,32)25-15-13-24(33-2)14-16-25/h3-16,30H,17-20H2,1-2H3/b6-5+
InChI Key	LLLQTDSSHZREGW-AATRIKPKSA-N