EDTA trisodium salt是一种金属螯合剂 (与

Ethylenediaminetetraacetic acid trisodium salt (EDTA trisodium salt; Trisodium EDTA) is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid trisodium salt has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid trisodium salt decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid trisodium salt can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid can be used for coronary artery disease and neural system disease research^{[1][2][3][4][5][6][7]}.

Ethylenediaminetetraacetic acid 对铜绿假单胞菌 (P. aeruginosa) 和粪单胞菌 (a. faecalis) 的细胞壁具有较强的杀菌作用^[4]。
Ethylenediaminetetraacetic acid (0.005-0.01 M) 在污染粉质粘壤土土柱中具有较好的重金属萃取作用， 能以浓度依赖的方式萃取出 Pb、 Cd 和 Zn，萃取效率顺序为 Pb > Cd > Zn^[6]。
Ethylenediaminetetraacetic acid (1.2 mM) 在 HEK293T 细胞中通过激活 t 细胞死亡相关基因 8 (TDAG8) 来增强 CRE 驱动启动子的活性，从而增强了细胞中 cAMP 的产生^[7]。

Ethylenediaminetetraacetic acid (60 mg/kg; 腹腔注射; 每周三次连续三周 ) 在 CCl₄ 诱导的肝纤维化大鼠中可以降低肝的纤维化、脂质过氧化和肝脏炎症，具有抗氧化和抗炎活性^[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

358.00

C₁₀H₁₃N₂Na₃O₈

150-38-9

固体

White to off-white

依地酸三钠盐

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Chumanov RS, et al. Artifact-inducing enrichment of ethylenediaminetetraacetic acid and ethyleneglycoltetraacetic acid on anion exchange resins. Anal Biochem. 2011 May 1;412(1):34-9.  [Content Brief]

  [2]. Banfi G, et al. The role of ethylenediamine tetraacetic acid (EDTA) as in vitro anticoagulant for diagnostic purposes. Clin Chem Lab Med. 2007;45(5):565-76.  [Content Brief]

  [3]. Ibad A, et al. Chelation therapy in the treatment of cardiovascular diseases. J Clin Lipidol. 2016 Jan-Feb;10(1):58-62. [Content Brief]

  [4]. Gray GW, et al. The effect of ethylenediaminetetra-acetic acid on the cell walls of some gram-negative bacteria. J Gen Microbiol. 1965 Jun;39(3):385-99.  [Content Brief]

  [5]. González-Cuevas J, et al. Ethylenediaminetetraacetic acid induces antioxidant and anti-inflammatory activities in experimental liver fibrosis. Redox Rep. 2011;16(2):62-70.  [Content Brief]

  [6]. Naghipour D, et al. Remediation of heavy metals contaminated silty clay loam soil by column extraction with ethylenediaminetetraacetic acid and nitrilo triacetic acid[J]. Journal of Environmental Engineering, 2017, 143(8): 04017026.

  [7]. Deai M, et al. Ethylenediaminetetraacetic acid (EDTA) enhances cAMP production in human TDAG8-expressing cells. Biochem Biophys Res Commun. 2022 Oct 20;626:15-20.  [Content Brief]