Cinchophen 是一种具有口服活性的非甾体抗炎试剂 (

Cinchophen is a potent and orally active non-steroidal anti-inflammatory agent, has analgesic and antimicrobial effects. Cinchophen can be used for the research of arthritis and some liver diseases^[1].

Cinchophen (oral gavage; 25-44 mg/kg; twice daily) combines prednisolone ( 0.125-0.220 mg/kg; twice daily) for 14 days is effective in dogs with osteoarthritis and well tolerated. The combination exhibits significantly improved lameness, weight bearing, joint mobility and stiffness scores and is similar in clinical efficacy to phenylbutazone^[2].
The kinetics and efficacy of a cinchophen prednisolone combination preparation (PLT) is tested. Cinchophen administation at a dose rate of 12.5 mg/kg intravenously exhibits a volume of distribution (V_d area) of 0.13 L/kg, shows a clearance rate (Cl) of 0.15 L/h and a half-life (t_1/2β) of 7.92 hours. The plasma concentration time curve (AUC0-∞) is 1187.0 μ/ml.h in dogs^[2].
Cinchophen administation (oral gavage; 12.5 mg/kg; single dose) exhibits a mean maximum plasma concentration (C_max) of 77.75 μg/ml and the time of Cmax (t_max) is 2.76 hours. The plasma concentration time curve (AUC_0-∞) is almost as large following oral as intravenous administration indicating an oral bioavailability (F) of 87.21%^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

249.26

C₁₆H₁₁NO₂

132-60-5

辛可芬

Room temperature in continental US; may vary elsewhere.

DMSO : 83.33 mg/mL (334.31 mM; Need ultrasonic)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
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• 1.

  请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

  Solubility: ≥ 2.5 mg/mL (10.03 mM); Clear solution

• 2.

  请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

  Solubility: ≥ 2.08 mg/mL (8.34 mM); Clear solution

• 3.

  请依序添加每种溶剂： 10% DMSO 90% corn oil

  Solubility: ≥ 2.08 mg/mL (8.34 mM); Clear solution

• [1]. R.G. Snyder, M.D, et al. The use of cinchophen in the treatment of chronic arthritis. THE AMERICAN ASSOCIATION FOR THE STUDY AND CONTROL OF RHEUMATIC DISEASE

  [2]. Q. A. McKellar, et al. Pharmacokinetics and clinical efficacy of a cinchophen and prednisolone combination in the dog. Jsap. Volume32, Issue2. February 1991