Chlorhexidine digluconate 双葡萄糖

Chlorhexidine digluconate is an antiseptic effective against a wide variety of gram-negative and gram-positive organisms. Target: Antibacterial Chlorhexidine digluconate is a chemical antiseptic. It is effective on both Gram-positive and Gram-negative bacteria, although it is less effective with some Gram-negative bacteria. It has both bactericidal and bacteriostatic mechanisms of action, the mechanism of action being membrane disruption, not ATPase inactivation as previously thought. It is also useful against fungi and enveloped viruses, though this has not been extensively investigated. Chlorhexidine digluconate is harmful in high concentrations, but is used safely in low concentrations in many products, such as mouthwash and contact lens solutions [1, 2].

897.76

C₃₄H₅₄Cl₂N₁₀O₁₄

18472-51-0

葡萄糖酸氯己定；葡萄糖酸洗必泰；氯己定二葡糖酸盐；洗必泰葡萄糖酸盐

Room temperature in continental US; may vary elsewhere.

Solution, -20°C, 2 years

H₂O : 100 mg/mL (111.39 mM; Need ultrasonic)

DMSO : ≥ 38 mg/mL (42.33 mM)

* "≥" means soluble, but saturation unknown.

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

• 1.

  请依序添加每种溶剂： PBS

  Solubility: 100 mg/mL (111.39 mM); Clear solution; Need ultrasonic

• [1]. Jenkins, S., M. Addy, and W. Wade, The mechanism of action of chlorhexidine. A study of plaque growth on enamel inserts in vivo. J Clin Periodontol, 1988. 15(7): p. 415-24. [Content Brief]

  [2]. Maki, D.G., M. Ringer, and C.J. Alvarado, Prospective randomised trial of povidone-iodine, alcohol, and chlorhexidine for prevention of infection associated with central venous and arterial catheters. Lancet, 1991. 338(8763): p. 339-43. [Content Brief]