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详见说明
Pentamidine isethionate
充足
medchemexpress(MCE)
140-64-7
50mg
生物活性 | Pentamidine isethionate (MP-601205 isethionate) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine isethionate inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine isethionate is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine isethionate has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities[1][2][3][4]. |
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IC50 & Target | IC50: 2.5 μM (Leishmania infantum)[2] |
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体外研究 (In Vitro) |
Pentamidine (0-10 µg/mL; 6 days; WM9, DU145, C4-2, Hey, WM480, and A549 cells) treatment inhibits the growth of cancer cells in a concentration-dependent manner[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[1]
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体内研究 (In Vivo) |
Pentamidine (0.25 mg/mouse; intramuscular injection; every 2 days; for 4 weeks; athymic nude mice) treatment markedly inhibits the growth of WM9 human melanoma tumors in nude mice[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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Clinical Trial |
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分子量 | 592.68 |
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Formula | C23H36N4O10S2 |
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CAS 号 | |||||||||||||||||||||
中文名称 | 喷他脒羟乙磺酸盐;依西酸喷他脒;戊双氧苯脒; |
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运输条件 | Room temperature in continental US; may vary elsewhere. |
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储存方式 | 4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
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溶解性数据 | In Vitro: H2O : 100 mg/mL (168.73 mM; Need ultrasonic) DMSO : 100 mg/mL (168.73 mM; Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
*以上所有助溶剂都可在 MCE 网站选购。 |
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参考文献 |
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