手机验证
4°C
详见说明
Ivosidenib
充足
杭州昊鑫生物
1448347-49-6
5mg
生物活性 | Ivosidenib (AG-120) is an orally active inhibitor of isocitrate dehydrogenase 1 mutant (mIDH1) enzyme, it exhibits profound d-2-hydroxyglutatrate (2-HG) lowering in vivo. Ivosidenib (AG-120) has the potential for AML therapy due to its acceptable safety profile and clinical activity[1]. |
||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IC50 & Target | 12 nM (mouse IDH1R132H)[1] |
||||||||||||||||||||
体外研究 (In Vitro) |
Ivosidenib (AG-120) (0-13 μM; 48 hours) inhibits several IDH1-R132 mutants with potency similar IC50 values: IDH1-R132H (IC50=12 nM); IDH1-R132C (IC50=13 nM); IDH1-R132G (IC50=8 nM); IDH1-R132L (IC50=13 nM); IDH1-R132S (IC50=12 nM), respectively[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
||||||||||||||||||||
体内研究 (In Vivo) |
AG-120 (gavage administration; 50 mg/kg and 150 mg/kg) declines tumor 2-HG concentration rapidly, with maximum inhibition (92.0% and 95.2% at the 50 mg/kg and 150 mg/kg doses, respectively) achieved at -12 h post dose[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
|
||||||||||||||||||||
Clinical Trial |
|
||||||||||||||||||||
分子量 | 582.96 |
||||||||||||||||||||
性状 | Solid |
||||||||||||||||||||
Formula | C28H22ClF3N6O3 |
||||||||||||||||||||
CAS 号 | |||||||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. |
||||||||||||||||||||
储存方式 |
|
||||||||||||||||||||
溶解性数据 | In Vitro: DMSO : ≥ 39 mg/mL (66.90 mM) * "≥" means soluble, but saturation unknown. 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
|
参考文献 |
---|
风险提示:丁香通仅作为第三方平台,为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全,合理判断,谨慎选购商品,商家和用户对交易行为负责。对于医疗器械类产品,请先查证核实企业经营资质和医疗器械产品注册证情况。