生物活性
UNC 669, a ligand for a methyl-lysine binding domain, is a potent L3MBTL1 (IC50=4.2 uM) and L3MBTL3 (3.1 uM) inhibitor[1].
IC50 & Target
IC50: 4.2 uM/3.1 uM (L3MBTL1/L3MBTL3)[1]
体外研究
(In Vitro)
L3MBTL1, a paralogue of Drosophila tumor suppressor lethal(3)malignant brain tumor (l(3)mbt), binds histones in a methylation state-dependent manner and contributes to higher order chromatin structure and transcriptional repression. Similar to L3MBTL1, the closely related protein, L3MBTL3, also contains three MBT repeats and has been shown to play a role in meduloblastoma formation and normal hematopoiesis in human
分子量
338.24
性状
Solid
Formula
C15H20BrN3O
CAS 号
1314241-44-5
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro:
DMSO : 50 mg/mL (147.82 mM; Need ultrasonic)
配制储备液
浓度溶剂体积质量 1 mg 5 mg 10 mg
1 mM 2.9565 mL 14.7824 mL 29.5648 mL
5 mM 0.5913 mL 2.9565 mL 5.9130 mL
10 mM 0.2956 mL 1.4782 mL 2.9565 mL
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: