生物活性
BMS-983970 is an oral pan-Notch inhibitor for the treatment of multiplecancers[1].
IC50 & Target
Notch[1]
体内研究
(In Vivo)
BMS-983970 demonstrates anti-tumor activity in T-cell acute lymphoblastic leukemia (T-ALL) and solid tumor xenograft models[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
518.50
性状
Solid
Formula
C26H26F4N4O3
CAS 号
1584713-87-0
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro:
DMSO : ≥ 50 mg/mL (96.43 mM)
* "≥" means soluble, but saturation unknown.
配制储备液
浓度溶剂体积质量 1 mg 5 mg 10 mg
1 mM 1.9286 mL 9.6432 mL 19.2864 mL
5 mM 0.3857 mL 1.9286 mL 3.8573 mL
10 mM 0.1929 mL 0.9643 mL 1.9286 mL
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: