产品背景:
Glucocorticoid-induced TNFR-related protein (GITR) is also known as Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), activation-inducible TNFR family receptor (AITR), CD antigen CD357, which is a member of the tumor necrosis factor receptor (TNF-R) superfamily. GITR is receptor for TNFSF18, which seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR also mediated NF-kappa-B activation via the TRAF2/NIK pathway.
产品描述:
Rat GITR, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 12.1 kDa. The predicted N-terminus is Gln 20. The reducing (R) protein migrates as 21 kDa in SDS-PAGE.