活性:
Measured by its ability to bind Human EGF, Tag Free (Cat# EGF-H4114) in the SPR assay (Biacore 2000) with an estimated KD of 50nM.
产品背景:
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer.
产品描述:
Human EGF R, Strep Tag is fused with twin strep tag at the C-terminus, and has a calculated MW of 76.1 kDa. The predicted N-terminus is Leu 25. The reducing (R) protein migrates as 110-115 kDa in SDS-PAGE due to glycosylation.