RKO-E6人结肠癌转基因细胞|RKO-E6细胞|人结肠癌转

细胞名称：	RKO-E6人结肠癌转基因细胞【带STR鉴定报告】
货号：	HTX1672
培养基：	89%培养基+10%FBS+1%双抗
生长状态：	良好
简介：	RKO-E6 cells are a human colorectal carcinoma cell line derived from the RKO cell line through additional mutagenesis. These cells are commonly used in cancer research, particularly focusing on colorectal cancer. The E6 variant of the RKO line offers a distinct profile that is useful for examining the effects of specific genetic manipulations and studying the molecular mechanisms of tumorigenesis and metastasis in colorectal cancer. RKO-E6 cells are characterized by several unique features, including alterations in genes related to cell cycle regulation, apoptosis, and DNA repair pathways.
相关检测：	RKO-E6人结肠癌转基因细胞存种的活性检测；细菌、真菌、霉菌污染物检测；衣原体、支原体检测（RKO-E6人结肠癌转基因细胞）
背景描述：	RKO-E6细胞系是用脂质体法转染pCMV-E6的结肠癌RKO细胞系。该细胞含有稳定整合受控於巨细胞病毒启动子的人乳头状病毒（HPV）E6癌基因。RKO-E6细胞系和它的母系RKO一起可用于研究p53缺失引起的细胞参数改变p53介导的转录和凋亡等。

 

相关应用：PubMed=8387205;
Kessis T.D., Slebos R.J.C., Nelson W.G., Kastan M.B., Plunkett B.S., Han S.M., Lorincz A.T., Hedrick L., Cho K.R.
Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage.
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