- ￥250 - 1300
- MedChemExpress(MCE)
- 美国
- HY-N0256
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
465-99-6
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥550.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥250.0 |
| 规格： | 10 mg | 产品价格： | ￥400.0 |
| 规格： | 25 mg | 产品价格： | ￥790.0 |
| 规格： | 50 mg | 产品价格： | ￥1300.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
Hederagenin
CAS No. : 465-99-6
MCE 国际站：Hederagenin
产品活性：Hederagenin 是三萜皂苷，具有口服活性和抗肿瘤活性。Hederagenin 能够抑制细胞中由于 LPS 刺激引起的 iNOS，COX-2，和 NF-κB 的表达。Hederagenin 还增加癌细胞中 ROS 产生，破坏线粒体膜电位，诱导细胞凋亡 (apoptosis)。Hederagenin 还增加癌细胞对 Cisplatin (HY-17394) 和 Paclitaxel (HY-B0015) 敏感，增强诱导的细胞凋亡。Hederagenin 对酒精性肝损伤也有预防潜力。
研究领域：Immunology/Inflammation | NF-κB
作用靶点：COX | NF-κB
In Vitro: Hederagenin (1 μM, 2 μM; 48 h) disrupts mitochondrial membrane potential, increases intracellular reactive oxygen species (ROS) content, and has a cytotoxic effect on cancer cells.
Hederagenin (1 μM, 2 μM; 48 h) induces apoptosis in human colon cancer LoVo cells, upregulates apoptosis-related proteins (Bax), and reduces apoptosis inhibitory proteins (Bcl-2, Bcl-xL, and Survivin) levels.
Hederagenin (50 μM; 4 h) also blocks autophagic flux-induced ROS accumulation and enhances the cytotoxicity of Cisplatin and Paclitaxel in lung cancer cells.
In Vivo: Hederagenin (25 mg/kg; po; 11 d) alone did not affect tumor growth in NCI-H1299 xenograft mice. However, it has a synergistic effect with Cisplatin (1 mg/kg) to inhibit tumor growth.
Hederagenin (50 mg/kg; po; once daily for 21 days) exerts anti-inflammatory and anti-apoptotic activities and reduces liver damage induced by 25% ethanol in mice.
相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | NF-κB Signaling Compound Library | Stem Cell Signaling Compound Library | Natural Product Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Antioxidant Compound Library | Differentiation Inducing Compound Library | Lipid Compound Library | Oxygen Sensing Compound Library | Ferroptosis Compound Library | Medicine Food Homology Compound Library | Terpenoids Library | Pyroptosis Compound Library | Traditional Chinese Medicine Active Compound Library | FDA Approved & Pharmacopeial Drug Library | Anti-Breast Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Anti-Obesity Compound Library | Transcription Factor-Targeted Library | Anti-Liver Cancer Compound Library | Anti-Cancer Natural Product Library | Antidepressant Compound Library | Anti-inflammatory Traditional Chinese Medicine Active Compound Library | Plant-Sourced Natural Product Library | Anti-Prostate Cancer Compound Library | Cancer Stem Cells Compound Library | Pain-Related Compound Library | Phorbol 12-myristate 13-acetate | Bortezomib | BAY 11-7082 | TAK-243 | Acetaminophen | JSH-23 | Indomethacin | Celecoxib | Sulfasalazine | Shikonin | EIPA | Pyrrolidinedithiocarbamate ammonium | Triptolide | Aspirin | Dihydroartemisinin | Baicalin | Oxidopamine hydrobromide | Deferiprone | Parthenolide | Diclofenac | BAY 11-7085 | 5-Aminosalicylic Acid | CBL0137 hydrochloride | Rocaglamide | Betulinic acid | Isoginkgetin | Gallic acid | Ibuprofen | SN50
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验有5%或1%，因此称95%或99%可信区间。下面用实例说明其求法。 95%可信区间 X-t0.05,νSX 99%可信区间 X-t0.05,νSX 例6.2 上面抽样实验中第1号样本的均数为488.6，标准差为61.65，例数10，自由度ν=10-1=9，试求95%与99%可信区间。 1．求标准误 95%可信区间 488.6-2.262(19.50) 99%可信
值即总体参数，而我们得到的却是样本统计量，用样本统计量估计或推论总体参数的过程叫参数估计。 本章第一节例6.1通过检查110个健康成人的尿紫质算得阳性率为10%，这是样本率，可用它来估计总体率，说明健康成人的尿紫质阳性率水平，这样的估计叫“点估计”。但由于存在抽样误差，不同样本（如再检查110人）可能得到不同的估计值。因此我们常用“区间估计”总体率（或总体均数）大概在那一个范围内，这个范围就叫可信区间。区间小的一端叫下限，大的一端叫上限。常用的有95%可信区间与99%可信区间。根据同一资料
462 463 465 466 468 469 470 471 472 473 476 477 478 479
技术资料暂无技术资料 索取技术资料
