一氧化氮A信号通路PCR 芯片Nitric Oxide Si

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Nitric Oxide Signaling Pathway PCR Array

一氧化氮A信号通路PCR 芯片

Product	Species	Technology	Cat. No.
Nitric Oxide Signaling Pathway PCR Array	Human	Gene Expression	PAHS-062Z
Nitric Oxide Signaling Pathway PCR Array	Mouse	Gene Expression	PAMM-062Z
Nitric Oxide Signaling Pathway PCR Array	Rat	Gene Expression	PARN-062Z

Nitric Oxide Signaling Pathway RT² Profiler™ PCR Array profiles the expression of 84 genes whose expression is controlled by or involved in signaling by the second messenger nitric oxide (NO). Nitric oxide is a dynamic and bioreactive molecule that can both participate in and inhibit the genesis of disease. Its ability to have an impact on a wide range of physiological events stems from its capacity to reversibly alter the expression of specific genes and the activities of a wide range of proteins and signaling pathways. This array contains genes involved in nitric oxide biosynthesis, superoxide metabolism and genes involved in response to oxidative stress. Also included are genes induced by or repressed by NO, which can be used as indicator for the activation of NO pathway in your cell system. Using real-time PCR, you can easily and reliably analyze expression of a focused panel of genes related to the Nitric Oxide signaling with this array.
一氧化氮A（NO）信号通路RT2 ProfilerTM PCR Array包含了表达受第二信使NO控制及参与NO信号通路的84个基因。NO是参与和抑制疾病发生的动态生物效应分子。NO分子能够可逆地改变特异基因的表达，和许多蛋白的活性以及可逆影响信号通路，从而能够影响许多生理活动。本芯片包括参与NO生物合成、过氧化物代谢的基因和参与氧化应激反应的基因。还包括被NO诱导或抑制的基因，这些基因能够作为细胞体系中NO信号通路激活的指标。通过实时定量PCR的方法，研究者即能够利用该芯片简单可靠地同时检测NO信号通路相关基因的表达。
Nitric Oxide Biosynthesis:
Oxidoreductases:NOS1 (nNOS), NOS2 (iNOS), NOS3 (eNOS), NQO1.
Nitric Oxide Biosynthesis Regulation:DYNLL1, GLA, HSP90AB1 (HSPCB), IL10, INS, NOS1AP.
Other Genes:AKT1, ARG2, DDAH2, DYNLL1, EGFR, GCH1, GCHFR.
Genes Induced by Nitric Oxide:CDKN1A (p21CIP1/WAF1), IL8, JUN, VEGFA.
Genes Suppressed by Nitric Oxide:CCNA1, MYB, TROAP.
Nitric Oxide Signaling Pathway:CAMK1, DLG4 (PSD95), GRIN2D, NOS1 (nNOS), PPP3CA, PRKAR1B, PRKCA.
Superoxide Metabolism:
Superoxide Release:ALOX12, DUOX1, DUOX2, NOX5, PRG3.
Oxidoreductases:ALOX12, DUOX1, DUOX2, NOS2, NOX5, SOD1, SOD2, SOD3.
Peroxidases:DUOX1, DUOX2.
Other Genes:CCS, NCF1, NCF2, PREX1.
Response to Oxidative Stress:
Anti-Apoptosis:MPO, MTL5, NME5, PRDX2, RNF7.
Antioxidants:APOE, MT3, VIMP, SOD1, SOD3, SRXN1.
Glutathione Peroxidases:GPX1, GPX2, GPX3, GPX4, GPX5, GPX6.
Oxidoreductases:CAT, EPX, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, LPO, MPO, MSRA, PRDX2, PRDX6, SOD1, SOD2, SRXN1, TPO, TXNRD2.
Peroxidases:CSDE1, CYGB, EPX, GPR156, LPO, MPO, PRDX2, PRDX5, PRDX6 (AOP2), TPO, TTN.
Transcription Regulators:CSDE1, FOXM1, GLRX2, SCRT2, SIRT2, SOD2.
Other Genes:ATOX1, DUSP1 (PTPN16), GSS, KRT1, MBL2, NUDT1, OXR1, PNKP, PRNP, SCARA3, SEPP1, SGK2.