Briciclib布瑞西利,865783-99-9

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Briciclib

CAS No. : 865783-99-9

MCE 国际站：Briciclib

产品活性：Briciclib (ON 014185) 是一种 ON 013100 衍生物，具有靶作用于 eIF4E 对抗固体肿瘤的潜力。

研究领域：Cell Cycle/DNA Damage  |  Autophagy

作用靶点：Eukaryotic Initiation Factor (eIF)  |  Autophagy

In Vitro: Briciclib has the potential in targeting eIF4E. Briciclib shows inhibitory activity against the proliferation of mantle cell leukemia (EKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, and FLO-1) cancer cell lines with GI₅₀s of 9.8-12.2 nM, and with no toxicity on normal endothelial cells. Briciclib dose-dependently reduces the expression of cyclin D1 and c-Myc in breast and MCL cancer cell lines within 8 hours.

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