STING-IN-5,2920064-17-9

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

STING-IN-5

CAS No. : 2920064-17-9

MCE 国际站：STING-IN-5

产品活性：STING-IN-5 是一种有效的 STING 抑制剂，在巨噬细胞中抑制 LSP 诱导的 NO 合成，IC₅₀ 为 1.15 μM。STING-IN-5 抑制炎症反应。STING-IN-5 可用于研究抗炎疾病和败血症。

研究领域：Immunology/Inflammation

作用靶点：STING

In Vitro: STING-IN-5 (compound 30) (40 μM; 24 h) exhibits less effect on RAW264.7 cell viability.
STING-IN-5 (2.5 and 5 μM; 2 h) inhibits NO production in LPS-stimulated RAW264.7 with inhibition rate of 69.28 ± 2.36 and 78.66 ± 2.73 at 2.5 and 5 μM, respectively, and exhibits IC₅₀ of 1.15 ± 0.15 μM.
STING-IN-5 (0.5-2 μM; 2 h) suppresses STING, as well as TBK1/IRF3/NF-κB activation.

In Vivo: STING-IN-5 (1.25-5 mg/kg; i.g.; once daily; for 3 days) have an obvious protective effect on acute liver injury in septic mice.
Pharmacokinetic Parameters of STING-IN-5 in male Sprague-Dawley rats.

Tmax (h)	Cmax (ng/mL)	AUC0-t (ng/mL·h)	AUC0-∞ (ng/mL·h)	T1/2 (h)	MRT0-t (h)	MRT0-∞ (h)
1	66.52	81.08	135.7	1.11	0.99	2.02

相关产品：CCCP  |  H-151  |  Vadimezan  |  C-176  |  2',3'-cGAMP sodium  |  MSA-2  |  ADU-S100 disodium salt  |  Omaveloxolone  |  SN-011  |  SR-717  |  diABZI STING agonist-1 trihydrochloride  |  cGAMP disodium  |  c-di-AMP disodium  |  STING-IN-2  |  STING agonist-3  |  Cyclic-di-GMP diammonium  |  STING agonist-1  |  C-178  |  IACS-8803 disodium  |  STING agonist-4  |  PROTAC STING Degrader-1  |  STING-IN-3  |  diABZI-C2-NH2  |  E7766 diammonium salt  |  SN-001

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds