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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
Peptide (C)TASEHSREPSAAGRLsD, corresponding to amino acid residues 465-481 (Intracellular loop between domains I and II) of rat NaV1.1 (Accession : P04774).
- 亚型:
IgG
- 形态:
Liquid
- 保存条件:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4℃. For long-term storage, aliquot and store at -20℃ or below. Avoid multiple freeze-thaw cycles.
- 克隆性:
Polyclonal
- 标记物:
Unconjugated
- 适应物种:
Human, Mouse, Rat
- 保质期:
12 months from the shipping date of the product.
- 抗原来源:
Rat
- 目录编号:
GTX54841
- 级别:
Primary Antibodies
- 库存:
Available
- 供应商:
GeneTex
- 宿主:
Rabbit
- 应用范围:
WB, ICC/IF, IHC-Fr, IP
- 浓度:
0.6 mg/ml(Please refer to the vial label for the specific concentration.)
- 靶点:
Nav1.1
- 抗体英文名:
Nav1.1 antibody
- 抗体名:
Nav1.1 抗体
- 规格:
50 μl
ICC/IF analysis of PFA-fixed rat DRG cells using GTX54841 Nav1.1 antibody.
Panel A : Primary antibody
Panel B : DNA dye Hoechst 33342
Panel C : Merged images of panels A and B
Dilution : 1:200
WB analysis of rat brain membrane lysate using GTX54841 Nav1.1 antibody preincubated with or without immunogen peptide.
Dilution : 1:200
IHC-Fr analysis of mouse cerebellum tissue using GTX54841 Nav1.1 antibody.
Panel A : The distribution of NaV1.1 (red) forms a band (arrows) in the molecular layer (Mol), close to the Purkinje cell bodies.
Panel B : Purkinje nerve cells are stained with mouse anti-Parvalbumin (green).
Panel C : Confocal merge of NaV1.1 and Parvalbumin.
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文献和实验Cell 子刊:颜宁与西湖大学申怀宗团队合作解析 Nav1.7 高分辨率结构,有望助力止痛药研发
,Nav1.7,由 SCN9A 编码,主要在背根神经节神经元中表达,是一种很有希望的止痛药物靶点,在认知信号传导中发挥重要作用。Nav1.7 调节感觉神经元的兴奋性,并有助于几种感官模式的认知。SCN9A 的突变与原发性红热痛、与通道病相关的疼痛不敏感和阵发性极度疼痛障碍有关。 研究人员之前报道过人类 Nav1.7 的结构,在之前的研究中,一种疾病变体 Nav1.7(E406K)由于其增强了重组表达水平而被选择使用。将毒素混合后用于结构解析,最终获得了分辨率均为 3.2 Å 的低温 EM 结构
Generation of Antibody Molecules Through Antibody Engineering
been overcome to a large extent using genetic-engineering techniques to produce chimeric mouse/human and completely human antibodies. Such an approach is particularly suitable because of the domain structure of the antibody molecule ( 2 ), where functional
The importance of antibody molecules was first recognized in the 1890s, when it was shown that immunity to tetanus and diphtheria was caused by antibodies against the bacterial exotoxins (1 ). Around the same time, it was shown that antisera
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