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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
HHGV678
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
10 mM * 1 mL/5 mg/10 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥866.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥700.0 |
| 规格： | 10 mg | 产品价格： | ￥900.0 |
| 规格： | 50 mg | 产品价格： | ￥1900.0 |
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Flumatinib
CAS No. : 895519-90-1
MCE 国际站：Flumatinib
产品活性：Flumatinib (HHGV678) 是一种具有口服活性的选择性 Bcr-Abl 抑制剂，对 c-Abl，PDGFRβ 和 c-Kit 的 IC50 分别为 1.2 nM，307.6 nM 和 665.5 nM。
研究领域：Protein Tyrosine Kinase/RTK
In Vitro: Flumatinib (HH-GV-678) can predominantly inhibit the autophosphorylation of Bcr-Abl in K562 cell. In higher concentration, Flumatinib can inhibit the phosphorylation of c-Kit in Mo7e cell and the phosphorylation of PDGFR in Swiss3T3 cell, however, Flumatinib has no or little effect on other tyrosine kinase including EGFR, KDR, c-Src and HER2 [1]. Flumatinib (HHGV678) effectively overcame the drug resistance of certain KIT mutants with activation loop mutations (i.e., D820G, N822K, Y823D, and A829P) [2].
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