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- 保存条件：
4°C, sealed storage, away from moisture
- 英文名：
HHGV678 mesylate
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1449.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥400.0 |
| 规格： | 5 mg | 产品价格： | ￥1000.0 |
| 规格： | 10 mg | 产品价格： | ￥1650.0 |
| 规格： | 25 mg | 产品价格： | ￥3200.0 |
| 规格： | 50 mg | 产品价格： | ￥5000.0 |
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Flumatinib mesylate
CAS No. : 895519-91-2
MCE 国际站：Flumatinib mesylate
产品活性：Flumatinib (HHGV678) mesylate 是一种具有口服活性和选择性的 Bcr-Abl 抑制剂，对 c-Abl，PDGFRβ 和 c-Kit 的 IC50 分别为 1.2 nM，307.6 nM 和 665.5 nM。Flumatinib mesylate 抑制 Bcr-Abl 自身磷酸化以及 Stat5 和 Erk1/2 磷酸化。Flumatinib mesylate 在慢性粒细胞白血病模型中抑制肿瘤生长。
研究领域：Protein Tyrosine Kinase/RTK
In Vitro: Flumatinib mesylate (HH-GV-678) (0-1000 μM; 4, 7 and 10 days) blocks cellular Bcr-Abl autophosphorylation and Stat5 and Erk1/2 phosphorylation in K562 leukemia cells.
Flumatinib mesylate (HH-GV-678) (0-10 μM; 72 hours) remarkably decreases the number of cells in chronic myelogenous leukemia cell lines.
In Vivo: Flumatinib mesylate (HH-GV-678) (18-75 mg/kg; p.o.; Twice daily, for 14 days.) inhibits tumor growth in nude mice.
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