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- 2025年07月14日
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- 文献和实验
- 技术资料
- 保存条件：
见说明书
- 保质期：
＞1年
- 英文名：
Dorsomorphin Free Base
- 库存：
期货2-3周
- 供应商：
上海经科化学科技有限公司
- CAS号：
866405-64-3
- 规格：
5mg
供应商：上海经科化学科技有限公司
服务热线：400-0199-638
QQ:472482400(上海经科）
微信号：shjkchem
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本试剂(Dorsomorphin)
仅供科研实验使用,不得用于其他用途！
货 号：D-3197
名 称：Dorsomorphin
别 名：Dorsomorphin Free Base
C A S ：866405-64-3
分子量：399.49
分子式：C24H25N5O
纯 度：HPLC/TLC:>99%
说 明：Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO. Disposal: A.
文 献：Inhibition of bone morphogenetic protein (BMP) signaling by dorsomorphin during the early critical stage of differentiation of pluripotent embryonic stem (ES) cells promoted the development of the cardiomyocyte lineage, but at the expense of reduced differentiation of endothelial, smooth muscle, and hematopoietic cells. Hao, J., et al. "Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells." PLoS One 3: e2904 (2008). Dorsomorphin disrupted zebrafish angiogenesis, but not by blocking bone morphogenic protein (BMP) signaling. Dorsomorphin also showed significant "off-target" effects against the vascular endothelial growth factor (VEGF) pathway. Hao, J., et al. "In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors." ACS. Chem. Biol. 5: 245-253 (2010). Dorsomorphin reduced phosphorylation levels of SMAD1/5/8 in cells stimulated by BMP2, BMP4, BMP6, and BMP7 selectively, and blocked BMP-, hemojuvelin-, and interleukin 6-mediated hepcidin gene transcription and BMP-induced osteogenic differentiation. It also inhibited hepcidin transcription in iron-stimulated zebrafish and induced hyperferremia in iron-replete mice. Yu, P.B., et al. "Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism." Nat. Chem. Biol. 4: 33-41 (2008). The addition of dorsomorphin to the culture medium before treatment with differentiation inducers reduced lipid accumulation in 3T3-L1 cells. Suenaga, M., et al. "BMP Inhibition with dorsomorphin limits adipogenic potential of preadipocytes." J. Vet. Med. Sci. 72: 373-377 (2010). Dorsomorphin treatment of MCF7 breast carcinoma cells led to Bax redistribution from the cytoplasm to mitochondria and caused apoptosis at least partly by ceramide upregulation, and probably not by AMPK inhibition. Jin, J., et al. "AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells." J. Lipid Res. 50: 2389-2397 (2009). Insulin did not affect glucose transport in control cells but increased glucose uptake for serum-starved cells that was preventable by dorsomorphin. Ching, J.K., et al. "A role for AMPK in increased insulin action after serum starvation." Am. J. Physiol. Cell Physiol. 299: C1171-C1179 (2010). Dorsomorphin inhibited the growth of four colorectal cancer cell lines, caused G2/M arrest, and induced apoptotic or autophagic death. Yang, W.L., et al. "AMPK inhibitor compound C suppresses cell proliferation by induction of apoptosis and autophagy in human colorectal cancer cells." J. Surg. Oncol. 106: 680-688 (2012).
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文献和实验出 HSC。 对于人类接受 HSC 移植作为治疗白血病或淋巴瘤的手段，UCB 已成为可移植的 HSC 的重要来源。然而，存在于标准 UCB 样品中的 HSC 个数通常不足以治疗成人，因此，Prohema 提高 HSC 数量和其再植能力的作用就变得十分重要。 Dorsomorphin Dorsomorphin 及其衍生物是骨形态发生蛋白（BMP）受体的抑制剂：在人类中被称为活化素受体样激酶 2（ALK2，也被称为
细胞中上调 AMPK 活性时，观察到衰老细胞中各种 SASP 因子 mRNA 水平的下降；而在缺氧条件下，衰老细胞表达更高水平的磷酸化的 AMPK。 那么，缺氧是否通过引起 AMPK 活性的增强进而阻止 mTOR 信号通路及 SASP 的表达呢？通过外源性添加抑制 AMPK 活性的药物 dorsomorphin，发现可以恢复 mTOR 信号及 SASP 因子的表达。因此，这些数据表明，在生理性缺氧条件下，通过 AMPK 介导的 mTOR 信号的抑制，是 SASP 促炎因子表达和分泌受抑制的内在机制。 图片来源
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