Ombitasvir奥比他韦,1258226-87-7

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Ombitasvir

CAS No. : 1258226-87-7

MCE 国际站：Ombitasvir

产品活性：Ombitasvir 是一种 HCV NS5A 抑制剂，对 HCV 基因型 1-5 和 6a 的 EC₅₀ 值分别为 0.82-19.3 pM 和 366 pM。

研究领域：Anti-infection

作用靶点：HCV

In Vitro: Ombitasvir is active against the genotype 2a JFH-1 replicon, with an EC₅₀ of 0.82 pM, and the EC₅₀s of ombitasvir are 42 pM and 68 pM against the L28 and F28 variants of this genotype 6a replicon, respectively. In GT1a, variants M28V, L31V, and H58D confers 58- to 243-fold resistance to Ombitasvir. Single variants M28T, Q30R, and Y93C/S confers 800- to 8965-fold resistance, while Y93H/N confers >40000-fold resistance to Ombitasvir.

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