Branaplam,1562338-42-4

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Branaplam

CAS No. : 1562338-42-4

MCE 国际站：Branaplam

产品活性：Branaplam (LMI070; NVS-SM1) 是一种口服有效和选择性的 SMN2 拼接调节剂，对 SMN 的 EC₅₀ 为 20 nM。Branaplam 抑制 hERG，IC₅₀ 为 6.3 μM。Branaplam 在严重的脊髓性肌萎缩症 (SMA) 小鼠模型中可提高全长 SMN 蛋白并延长其生存期。

研究领域：Cell Cycle/DNA Damage  |  Membrane Transporter/Ion Channel

作用靶点：DNA/RNA Synthesis  |  Potassium Channel

In Vitro: Branaplam (LMI070; NVS-SM1) treatment induces changes in the levels of 175 genes in human fibroblasts.

In Vivo: Branaplam (LMI070; NVS-SM1; 3, 10, 30 mg/kg; oral) produces dose-dependent elevations of SMN2-FL transcript and SMN protein in brain and spinal cord.
?Branaplam (1 mg/kg of IV; 3 mg/kg of PO) has a CL of 25 mL/min/kg and an AUC of 3.03 μM?h.
?A single Branaplam (oral; 30 mg/kg) results in significant and durable SMN protein elevation in brain for up to 160 hours in C/+ mice.
?Branaplam (oral; 0.03, 0.1, 0.3, 1, 3 mg/kg) improves body weight and extendes lifespan in n SMNΔ7 mice.

相关产品：Drug Repurposing Compound Library Plus  |  Clinical Compound Library Plus  |  Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Membrane Transporter/Ion Channel Compound Library  |  Anti-Cancer Compound Library  |  Clinical Compound Library  |  Anti-Aging Compound Library  |  Drug Repurposing Compound Library  |  Orally Active Compound Library  |  Anti-Alzheimer's Disease Compound Library  |  Neurodegenerative Disease-related Compound Library  |  Targeted Diversity Library  |  Rare Diseases Drug Library  |  Potassium Channel Compound Library  |  Heterocyclic Compound Library  |  Membrane Protein-targeted Compound Library  |  Membrane Receptor-targeted Compound Library  |  Highly Selective Inhibitors Library  |  Highly Selective Activators Library  |  Ion Channel Compound Library  |  Cycloheximide  |  Actinomycin D  |  Oxaliplatin  |  Gemcitabine  |  Nigericin sodium salt  |  Carboplatin  |  Bleomycin sulfate  |  Mitomycin C  |  Cytarabine  |  Yoda 1  |  Methotrexate  |  ART558  |  Streptozotocin  |  Anisomycin  |  BAPTA-AM  |  Fludarabine  |  Thymidine  |  Minocycline hydrochloride  |  Hydroxyurea  |  Remdesivir  |  Daunorubicin hydrochloride  |  Brequinar  |  Capecitabine  |  α-Amanitin  |  CX-5461  |  Folic acid  |  Urolithin A  |  Epirubicin hydrochloride

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds