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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
518303-20-3
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1030.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥380.0 |
| 规格： | 5 mg | 产品价格： | ￥1000.0 |
| 规格： | 10 mg | 产品价格： | ￥1500.0 |
| 规格： | 50 mg | 产品价格： | ￥4500.0 |
| 规格： | 100 mg | 产品价格： | ￥6500.0 |
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UMI-77
CAS No. : 518303-20-3
MCE 国际站：UMI-77
产品活性：UMI-77是一种选择性的 Mcl-1 抑制剂，对 Mcl-1 具有高亲和力 (IC50= 0.31 μM)。UMI-77 结到 Mcl-1 的 BH3 结合沟， Ki 值为 490 nM，比作用于 Bcl-2 家族其他成员的选择性高。
研究领域：Apoptosis
作用靶点：Bcl-2 Family
In Vitro: Competitive binding curve of UMI-77 against Mcl-1 is obtained by FP based binding assay using fluorescent labeled Bid BH3 peptide with an IC50 of 1.87±0.22 μM. UMI-77 potently inhibits the cell growth of BxPC-3 and Panc-1 cell lines with IC50 values of 3.4 μM and 4.4 μM respectively, and shows 3 to 5 times less potency in inhibition of the cell growth of two other tested cell lines MiaPaCa-2 (12.5 μM) and AsPC-1 (16.1 μM). The cell growth inhibition potency of UMI-77 correlates with the highest expression of Mcl-1 and Bak, and lowest expression of Bcl-xL in the sensitive cell lines, BxPC-3 and Panc-1. Capan-2 cells are showing similar sensitivity to UMI-77 (IC50 of 5.5 μM) as BxPC-3 and Panc-1, although has low Mcl-1 levels[1].
In Vivo: UMI-77 exhibits moderate metabolic stability with a half-life of 45 minutes.The maximum tolerated dose (MTD) of UMI-77 in SCID mice is determined. Administered 60 mg/kg i.v. for 5 consecutive days per week for two weeks does not cause any loss in the animal weight and there is no obvious sign of toxicity during the course of the treatment. Increasing the dose to 80 mg/kg show severe animal weight loss (>20%), therefore 60 mg/kg is used as a therapeutic dose for the in vivo efficacy studies. Daily treatment with UMI-77 for 5 consecutive days a week for two weeks results in statistically significant tumor growth inhibition by 65% and 56% in comparison with the controls in day 19 (p<0.0001) and day 22 (p<0.003) respectively[1].
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文献和实验CD77 分子 CD77 常用单克隆抗体或代号： 38.13(BL- A),424/4A11 主要表达细胞： Bac [B] 分子质量(kDa)和结构： Globotriaocylceramide(Gb3) 功 能： 参与凋亡过程中跨膜信号转导 CD77 Aka globotriaosylceraminde, pK blood group Binds to Shiga
实验77 苍耳的光周期诱导 原理 植物在发育地程中需要有一定的光周期诱导才能进入性器官的分化，从而达到开花结实。苍耳是短日照植物，短的光周期诱导能促使其性器官分化，提早开花结实。 仪器 供短日处理的暗箱或暗室 小花盆 光照自控装置 双筒解剖镜 操作步骤 1．将苍耳种子播种
Genotype 1a HCV (H77S) Infection System
research, the parallel development of a tractable genotype 1a infection system (H77S virus) has provided significant advantages in assessing genotype 1-specific interventions, given the highly heterogeneous nature of HCV. H77S RNA contains five cell culture
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